Feb 24, 2016

Cellular aspects of gonadal atrophy in P-M hybrid dysgenesis

BioRxiv : the Preprint Server for Biology
Natalia V DorogovaLyudmila P Zakharenko

Abstract

Gonadal atrophy is the most typical and dramatic manifestation of intraspecific hybrid dysgenesis syndrome leading to sterility of Drosophila melanogaster dysgenic progeny. The P-M system of hybrid dysgenesis is primarily associated with germ cell degeneration during the early stages of Drosophila development at elevated temperatures. In the present study, we have defined the phase of germ cell death as beginning at the end of embryogenesis immediately following gonad formation. The early stages of germ cell formation in dysgenic flies showed sensitivity to developmental temperature increases at any stage of the Drosophila life cycle including the imago. Analysis of germ cell reactions to hybrid dysgenesis induction revealed significant changes in subcellular structure, especially mitochondria, prior to germ cell breakdown. The mitochondrial pathology can be the reason for the activation of cell death pathways in dysgenic germ cells and lead to gonadal atrophy.

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Mentioned in this Paper

Study
Biochemical Pathway
Drosophila
Germ Cell Tumor
Embryonic Development
Mitochondria
Cytopathic Effect
Germ Cells
Diptera
Psathyrella

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