Cellular basis of skin allograft rejection in mice: specific lysis of allogeneic skin components by non-T cells

Transplantation
N YamamotoR Yoshida

Abstract

It has been generally assumed that CD8+ T cells mediate direct lysis of allografts and that their growth, differentiation, and activation are dependent upon cytokine production by CD4+ T cells. However, both the generation of CD4- or CD8-deficient mice and adoptive transfer experiments with CD4+ T cells from CD8-deficient mice demonstrate that noncytotoxic CD4+ T cells alone are sufficient to induce skin or organ allograft rejection. Furthermore, we have reported that the major effector cells responsible for allografted-tumor (e.g., Meth A) rejection are allograft-induced macrophages (AIM) with MHC haplotype specificity. We characterized the macrophages migrating into the rejection site of allografted skin by immunohistochemical and in situ hybridization analyses using an antibody (K16.5) specific for AIM and a cDNA (pK30) encoding the antigen. To determine the in situ effector cells responsible for the rejection, we prepared both effector cells and target cells from the graft-graft bed border. The macrophages seemed to be morphologically (monocytic), phenotypically (K16.5+/pK30+), and functionally (cytotoxic against Meth A cells) AIM. The AIM population in bulk infiltrates taken from the rejection site was cytotoxic against al...Continue Reading

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Citations

May 16, 2002·Molecular Immunology·Vladimír HolánJana Pindjáková
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ryuichiro HirotaRyotaro Yoshida
Sep 19, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ryuichiro HirotaRyotaro Yoshida
Jul 16, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yukio YonedaRyotaro Yoshida
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satoko YamaguchiRyotaro Yoshida
Apr 13, 1999·Transplantation·E J WeringerH J Showell
Mar 9, 2000·Transplantation·Z HaskovaP M Stuart
May 8, 2000·Transplantation·R YoshimuraJ L Touraine
Feb 1, 2002·Transplantation·Jarmila PlskováJohn V Forrester
Jul 10, 2013·Transplantation·Junko Tashiro-YamajiRyotaro Yoshida
Apr 25, 2012·Gene·Junko Tashiro-YamajiRyotaro Yoshida
Jun 14, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Jana PindjákováVladimír Holán
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T H FlynnD F P Larkin
Jun 30, 2015·Journal of Tissue Engineering and Regenerative Medicine·Michaela HajkovaMagdalena Krulova
Apr 17, 2015·Plastic and Reconstructive Surgery. Global Open·Shogo MaedaRyotaro Yoshida
May 21, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mohammadreza PakyariErin Brown
Dec 19, 2007·Current Eye Research·Jerry Y Niederkorn
Feb 19, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ryotaro YoshidaTakahiro Kubota
Jan 10, 2003·Cell Transplantation·Daniel SkukJacques P Tremblay
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hayahito NomiRyotaro Yoshida
Sep 21, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ryotaro YoshidaTakahiro Kubota

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