Cellular bioenergetics changes in magnocellular neurons may affect copeptin expression in the late phase of sepsis

Journal of Neuroimmunology
Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha

Abstract

We investigated whether inflammatory mediators during cecal ligation and puncture (CLP)-induced sepsis may diminish copeptin expression in magnocellular neurons, thus affecting arginine-vasopressin (AVP) synthesis. The transcript abundance of IL-1β, IL-1R1, iNOS and HIF-1α was continuously elevated. IL-1β, iNOS and cytochrome c protein levels progressively increased until 24h. Immunostaining for these proteins was higher at 6 and 24h, as also seen in the annexin-V assay, while copeptin was continuously decreased. This suggests that increased IL-1β and NO levels may cause significant bioenergetics changes in magnocellular neurons, affecting copeptin expression and compromising AVP synthesis and secretion in the late phase of sepsis.

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Citations

Jul 27, 2014·Peptides·Cristian Palmiere, Marc Augsburger
Jul 18, 2015·Molecular Neurobiology·Fazal WahabMaria Jose A Rocha
Sep 16, 2016·Molecular Neurobiology·Luis Henrique Angenendt da CostaMaria José Alves da Rocha
Jul 17, 2019·BMC Neuroscience·Robert H ThieleZhiyi Zuo
Jul 12, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Nicola Latronico, Carlo Alberto Castioni
Nov 1, 2016·Molecular Neurobiology·Carlos Henrique Rocha CatalãoMaria José Alves Rocha
Jun 12, 2020·Neurotoxicity Research·Carlos Henrique Rocha CatalãoMaria José Alves Rocha
Jan 9, 2021·Molecular Neurobiology·Luis Henrique Angenendt da CostaMaria José Alves Rocha
Mar 3, 2020·Journal of Neuroimmunology·Rafael Alves CazuzaChristie Ramos Andrade Leite-Panissi

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