PMID: 7539503Jul 1, 1995Paper

Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism

Journal of Virology
C S DukesJ B Weinberg

Abstract

CD4 is the predominant cell membrane protein that binds human immunodeficiency virus type 1 (HIV-1) gp120 and facilitates HIV-1 infection, but other membrane-associated molecules may be involved in determining HIV-1 cellular infection. Our prior work had suggested that CD44, the transmembrane receptor for hyaluronan, might play a role in the infection of mononuclear phagocytes with HIV-1. In the present work, we have used cells of the CD4-positive, CD44-negative human T-lymphoblast cell line Jurkat to study the role of CD44 in HIV-1 infection and tropism. Cells were transfected with cDNA for the standard (S, or hematopoietic) CD44 isoform CD44S or the epithelial isoform CD44E. The resultant lines expressed appropriate CD44S or CD44E mRNA and protein. While the parent Jurkat cells, those transfected with vector alone, and those transfected with CD44E could be productively infected with only the lymphocytotropic strain HIV-1-LAI, cells transfected with CD44S were rendered susceptible to productive infection with the monocytotropic strains HIV-1-BaL and HIV-1-ADA. Also, CD44S-transfected cells displayed higher levels of infection with HIV-1-LAI than did the other transfected Jurkat cells. The transfected cell line cells all had co...Continue Reading

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Citations

Feb 1, 1997·Journal of Dental Research·N ShineN Düzgüneş
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Mar 6, 2002·The Journal of Experimental Medicine·Sina BavariM Javad Aman
Apr 1, 1997·Journal of Virology·M J Bouchard, V R Racaniello

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