Cellular changes in cultured mouse thyroid glands and islets of Langerhans

Transplantation
E L ParrK J Lafferty

Abstract

Islets of Langerhans cultured 7 days in vitro no longer contained any capillary endothelial cells, but their endocrine cells remained ultrastructurally normal up to 14 days. Vascular endothelial cells were also lost from cultured thyroid lobes, but more slowly. Thyroid endothelium was readily identified after 7 days of culture, although many cells appeared to be degenerating, and a few degenerating endothelial cells were still present after 14 days in culture. Erythrocytes and leukocytes in the lumina of thyroid vessels were observed to degenerate at about the same rate as the endothelial cells, while those in islet capillary lumina were largely washed out during isolation of the islets. Thyroid lymphatic endothelium and the numerous adipose cells present in this tissue also degenerated during the culture period. Follicle epithelial cells remained viable throughout the culture period, but the number of colloid droplets and endocytic vesicles they contained was markedly, decreased. Thyroid fibroblasts remained viable and appeared to enlarge and accumulate dense granules during culture. These cells were a prominent feature of thyroid lobes after 14 days of culture. Parathyroid tissue associated with the thyroid lobes showed viabl...Continue Reading

Citations

Dec 26, 2001·European Journal of Immunology·Ricardo Pimenta-AraujoAntonio Bandeira
Apr 1, 1984·World Journal of Surgery·K J Lafferty, S J Prowse
Feb 1, 1997·Transplantation Proceedings·M CoulombeR G Gill
Jan 19, 2000·Immunology Today·R M Smith, T E Mandel
Mar 17, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·S A WhiteM L Nicholson
Jan 1, 1996·Plastic and Reconstructive Surgery·S R StrasbergJ B Hay
Jun 15, 1997·Transplantation·F A MerchantA C Bovik
Dec 16, 1998·Xenotransplantation·C J SimeonovicP D Hodgkin
Jul 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Göran MattssonLeif Jansson
Apr 2, 2005·Upsala Journal of Medical Sciences·Göran Mattsson
Jun 22, 2005·Treatments in Endocrinology·Daniel M RidgwayRachel M Kimber
Dec 1, 1982·Immunology Today·D F NixonJ A Frelinger
Jan 1, 1983·Immunological Reviews·P K LalaV Colavincenzo
Dec 6, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Göran MattssonLeif Jansson
Apr 10, 2015·Upsala Journal of Medical Sciences·Guangxiang ZangAndreea Barbu
Dec 23, 2006·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Omaima M SabekA Osama Gaber
Apr 15, 2015·Biochimica Et Biophysica Acta·Sandrine LablancheEric Fontaine
Apr 30, 2002·Diabetes·Göran MattssonPer-Ola Carlsson
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K L WomerH Auchincloss
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Juliet EmamaulleeJohn F Elliott
Jul 17, 2020·Diabetes·Michael P DybalaManami Hara
Apr 26, 2015·The Journal of Biological Chemistry·Michael G SpeliosEitan M Akirav

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.