Cellular characterization of the gouty tophus: a quantitative analysis

Arthritis and Rheumatism
N DalbethJillian Cornish

Abstract

To characterize the cellular architecture of the tophus and to determine the presence of cytokines implicated in the initiation and resolution of gouty inflammation. Sixteen fixed, paraffin-embedded, uninfected tophus samples were surgically obtained from 12 patients with microscopically proven gout and were analyzed by quantitative immunohistochemistry. The number of cells present in the corona and fibrovascular zones of the tophus was analyzed by Genmod mixed models analysis. Numerous CD68+ mononucleated and multinucleated cells were present within the corona zone. Mast cells were identified in all tophus samples and at similar densities throughout the corona and fibrovascular zones. In contrast, neutrophils were rarely observed. Plasma cells were present in very high numbers within the corona zone. The overall number of CD20+ B cells was much lower. However, in 6 of 12 patients (50%), at least 1 B cell aggregate was present in the fibrovascular zone. Large numbers of cells expressing interleukin-1beta (IL-1beta) were observed in the corona zone. Transforming growth factor beta1 (TGFbeta1)-expressing mononucleated cells were also identified. The number of CD68+ cells correlated with the number of cells expressing IL-1beta (r ...Continue Reading

References

Apr 1, 1978·Arthritis and Rheumatism·P Hasselbacher, H R Schumacher
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Aug 19, 2000·The Journal of Infectious Diseases·N P JuffermansT van Der Poll
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S TakemuraC M Weyand
Nov 13, 2002·Arthritis and Rheumatism·R Clive LandisDorian O Haskard
Feb 7, 2003·Arthritis and Rheumatism·Paul A HessianMichael Chin
Jan 12, 2005·Arthritis Research & Therapy·Peter A Nigrovic, David M Lee
Jun 16, 2005·Rheumatology·N Dalbeth, D O Haskard
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Aug 4, 2006·The Journal of Clinical Investigation·Chun-Jen ChenKenneth L Rock
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jochen ZwerinaGeorg Schett
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uliana KanevetsYan Shi

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Citations

Jan 25, 2013·Seminars in Immunopathology·Ioannis MitroulisKonstantinos Ritis
Jun 7, 2013·Aging Clinical and Experimental Research·Francesco BolzettaGiuseppe Sergi
Jan 11, 2012·Nature Reviews. Rheumatology·Fiona M McQueenNicola Dalbeth
Feb 4, 2012·Current Opinion in Rheumatology·Nicola DalbethFiona M McQueen
Oct 23, 2012·International Journal of Rheumatic Diseases·Houheng SuYi Zhou
Dec 24, 2013·BMC Musculoskeletal Disorders·Nicola DalbethWilliam J Taylor
Jun 11, 2011·Arthritis Research & Therapy·Jade E Hollis-MoffattTony R Merriman
Nov 17, 2011·Arthritis Research & Therapy·Fiona M McQueenNicola Dalbeth
Aug 27, 2013·AJR. American Journal of Roentgenology·Gandikota GirishJon A Jacobson
Apr 16, 2013·Arthritis·Gandikota GirishDavid A Jamadar
Aug 20, 2014·Nature Reviews. Rheumatology·Pascal RichetteThomas Bardin
Jan 8, 2013·Current Rheumatology Reports·Nicola Dalbeth, Hyon K Choi
Jan 17, 2013·Postgraduate Medicine·Paul P Doghramji, Robert L Wortmann
May 9, 2014·Expert Opinion on Drug Metabolism & Toxicology·Pascal RichetteThomas Bardin
Sep 29, 2015·Current Medical Research and Opinion·F Perez-Ruiz, M A Becker
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Ashika Chhana, Nicola Dalbeth
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Nader GhasemlouClifford J Woolf
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Nicola Dalbeth, Anthony J Doyle
Dec 15, 2015·Clinical Biomechanics·Sarah StewartKeith Rome
Sep 16, 2015·Nature Reviews. Rheumatology·Eliseo PascualFrancisca Sivera
Oct 3, 2012·International Journal for Numerical Methods in Biomedical Engineering·J W FernandezK Mithraratne
Oct 13, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Xin FengWei Gao
Nov 30, 2014·Arthritis Research & Therapy·Humaira RasheedTony R Merriman
Aug 1, 2015·International Journal of Dermatology·John W FrewRichard M Haber
Feb 1, 2015·Annals of the Rheumatic Diseases·Nicola DalbethFiona M McQueen
May 24, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christian MaueröderMarkus H Hoffmann
Dec 6, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wei-Ting LiaoChung-Jen Chen
Mar 13, 2015·Current Rheumatology Reports·Ashika Chhana, Nicola Dalbeth
Dec 18, 2013·Seminars in Arthritis and Rheumatism·Ralph MelzerBernhard Krauss
Sep 29, 2015·Arthritis Care & Research·Hugh de LautourNicola Dalbeth
Oct 30, 2016·Lancet·Nicola DalbethLisa K Stamp
Aug 17, 2016·International Journal of Rheumatic Diseases·Shyamashis DasKaushik Basu
Oct 16, 2016·Rheumatic Diseases Clinics of North America·Patrick OmoumiAlexander So
Dec 7, 2016·Nature Medicine·Christiane ReinwaldMarkus Hoffmann

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