Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain.

Physiological Reviews
Rohini Kuner, Thomas Kuner

Abstract

Chronic, pathological pain remains a global health problem and a challenge to basic and clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been that the nature of neural circuits underlying the diverse components of the complex, multidimensional experience of pain is not well understood. Moreover, chronic pain involves diverse maladaptive plasticity processes, which have not been decoded mechanistically in terms of involvement of specific circuits and cause-effect relationships. This review aims to discuss recent advances in our understanding of circuit connectivity in the mammalian brain at the level of regional contributions and specific cell types in acute and chronic pain. A major focus is placed on functional dissection of sub-neocortical brain circuits using optogenetics, chemogenetics, and imaging technological tools in rodent models with a view towards decoding sensory, affective, and motivational-cognitive dimensions of pain. The review summarizes recent breakthroughs and insights on structure-function properties in nociceptive circuits and higher order sub-neocortical modulatory circuits involved in aversion, learning, reward, and mood and their modulation by endogenous GABAergi...Continue Reading

References

Apr 6, 1990·Science·W DenkW W Webb
Sep 25, 1986·Neuroscience Letters·S R Cohen, R Melzack
Dec 22, 1994·Nature·A D CraigA Blomqvist
Jun 10, 2000·Science·C J Woolf, M W Salter
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·William D WillisGlenn J Giesler
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Vania ApkarianDarren R Gitelman
Aug 13, 2005·European Journal of Pain : EJP·Harald BreivikDerek Gallacher
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeong S HanVolker Neugebauer
Mar 7, 2006·European Journal of Pain : EJP·Andreas HessKay Brune
Oct 21, 2006·Nature Reviews. Neuroscience·Herta FlorTroels Staehelin Jensen
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marwan N BalikiA Vania Apkarian
Mar 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shaaban A MousaMichael Schäfer
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jong H KimFrederick A Lenz
May 22, 2007·NeuroImage·Xavier Moisset, Didier Bouhassira
Nov 9, 2007·The Journal of Comparative Neurology·Kristóf GiberLászló Acsády
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Satoshi DeyamaMasabumi Minami
Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander GrohThomas Kuner
Mar 11, 2009·The Journal of Comparative Neurology·João M BrazAllan I Basbaum
Jul 21, 2009·Nature Protocols·Anthony HoltmaatLinda Wilbrecht
Oct 20, 2009·Cell·Allan I BasbaumDavid Julius
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard P DumPeter L Strick
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guangchen JiVolker Neugebauer
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng WeiWei Guo
Jun 25, 2010·The Journal of Comparative Neurology·Steve DavidsonGlenn J Giesler
Oct 16, 2010·Nature Medicine·Rohini Kuner
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Aleksandar DenicIstvan Pirko
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sylvia M GustinLuke A Henderson
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin AllenHannah Monyer

❮ Previous
Next ❯

Citations

Mar 16, 2021·Frontiers in Neuroscience·Micael TeixeiraJoelle Nsimire Chabwine
Mar 30, 2021·Neuroscience Letters·Yaping XueClaire Gaveriaux-Ruff
Apr 30, 2021·Frontiers in Psychiatry·William H RoughanMiguel E Rentería
May 14, 2021·Pain Reports·Michael J LacagninaPeter M Grace
Jun 3, 2021·Biomedicines·Myeong Seong BakSun Kwang Kim
Jun 16, 2021·Nature Reviews. Neuroscience·Linette Liqi Tan, Rohini Kuner
Jun 29, 2021·Trends in Neurosciences·Linette Liqi TanRohini Kuner
Aug 11, 2021·Pharmaceutics·Vimala N BharadwajDavid C Yeomans
Jun 30, 2021·The Journal of Pharmacology and Experimental Therapeutics·Alex Mabou TagneDaniele Piomelli
Nov 11, 2021·Science Translational Medicine·Selwyn JayakarClifford J Woolf
Nov 11, 2021·Science Translational Medicine·Nicole Mercer LindsayGrégory Scherrer
Nov 30, 2021·Journal of Diabetes Science and Technology·Natalie H Strand, Adam R Burkey
Jan 21, 2022·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Megan M Jorgensen, Brian D Burrell

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
fluorescence imaging
imaging techniques
imaging technique
dissection
transgenic
single cell sequencing

Software Mentioned

DREADD

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Neuroscience
Rohini Kuner, Herta Flor
Current Opinion in Supportive and Palliative Care
Michael H OssipovFrank Porreca
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Woojin Kim, Sun Kwang Kim
Development, Growth & Differentiation
Hiroshi KohsakaAkinao Nose
© 2022 Meta ULC. All rights reserved