PMID: 11934432Apr 6, 2002Paper

Cellular communication and bystander effects: a critical review for modelling low-dose radiation action

Mutation Research
Francesca BallariniOrazio Sapora

Abstract

Available data suggesting the occurrence of "bystander effects" (i.e. damage induction in cells not traversed by radiation) were collected and critically evaluated, in view of the development of low-dose risk models. Although the underlying mechanisms are largely unknown, cellular communication seems to play a key role. In this context, the main features of cellular communication were summarised and a few representative studies on bystander effects were reported and discussed. Three main approaches were identified: (1) conventional irradiation of cell cultures with very low doses of light ions; (2) irradiation of single cells with microbeam probes; (3) treatment with irradiated conditioned medium (ICM), i.e. feeding of unexposed cells with medium taken from irradiated cultures. Indication of different types of bystander damage (e.g. cell killing, gene mutations and modifications in gene expression) has been found in each of the three cases. The interpretations proposed by the investigators were discussed and possible biases introduced by specific experimental conditions were outlined. New arguments and experiments were suggested, with the main purpose of obtaining quantitative information to be included in models of low-dose ra...Continue Reading

References

Aug 1, 1992·Molecular & General Genetics : MGG·J J BoesenJ W Simons
Jul 3, 1986·Nature·T Hunter
Nov 1, 1994·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·S P CreganR E Mitchel
Apr 1, 1994·Free Radical Biology & Medicine·K YamaokaA Mori
Oct 29, 1997·International Journal of Radiation Biology·M FolkardB D Michael
Nov 28, 1997·International Journal of Radiation Biology·A OttolenghiM Merzagora
Nov 28, 1997·International Journal of Radiation Biology·C Mothersill, C Seymour
Feb 27, 1998·Frontiers in Bioscience : a Journal and Virtual Library·J E Trosko, R J Ruch
Mar 31, 1998·Environmental Health Perspectives·S Wolff
Sep 3, 1998·Mutation Research·A R Stebbing
Jan 9, 1999·International Journal of Radiation Biology·K M PriseB D Michael
Feb 11, 1999·International Journal of Radiation Biology·F BallariniA Ottolenghi
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L J WuT K Hei
Aug 24, 1999·Human & Experimental Toxicology·L E Feinendegen
Aug 24, 1999·Human & Experimental Toxicology·T Ikushima
Aug 24, 1999·Human & Experimental Toxicology·C A Waldren
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H ZhouT K Hei
Jun 7, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L ZhuangD N Sauder
Sep 30, 2000·Radiation Research·K H Chadwick, H P Leenhouts
Apr 17, 2001·Radiation Research·W FriedlandH G Paretzke
Oct 21, 2003·Radiation Research·G SchettinoB D Michael
Jan 22, 2005·Radiation Research·Tomoo FunayamaHiroshi Watanabe

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Citations

Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F Ballarini, A Ottolenghi
Dec 1, 2012·Computational and Mathematical Methods in Medicine·Kohei SasakiHiroyuki Date
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·J Leslie Redpath
Nov 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·David J BrennerMarco Zaider
Jun 10, 2008·Physics in Medicine and Biology·X George XuHarald Paganetti
Jul 29, 2009·International Journal of Radiation Biology·Angelica FacoettiAndrea Ottolenghi
Dec 17, 2010·International Journal of Radiation Biology·Hongying YangKathryn D Held
Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Aleksei V ErmakovNatalya N Veiko
Mar 12, 2013·Seminars in Radiation Oncology·Harald Paganetti, Peter van Luijk
Oct 22, 2013·Cancer Letters·Hongzhi WangWei Han
May 18, 2005·Cancer Letters·Gautam BanerjeeGovindarajan Raman
Aug 28, 2004·Cancer Letters·Waldemar M PrzybyszewskiJoanna Rzeszowska-Wolny
Jan 18, 2006·Mutation Research·M Ahmad Chaudhry
Jan 18, 2006·Mutation Research·C David Rollo
Aug 4, 2005·International Journal of Radiation Biology·A M GüerciA I Seoane
Sep 2, 2014·International Journal of Radiation Biology·Slavisa TubinRiccardo Maurizi Enrici
Jul 8, 2009·Radiation Research·Asima ChakrabortyRobert W Redmond
Aug 24, 2010·Radiation Research·Luca MariottiAndrea Ottolenghi
Sep 29, 2005·Radiation Research·Silvia GerardiRoberto Cherubini
Nov 19, 2004·Radiation Research·Natalia MedvedevaLeslie Braby
Mar 25, 2004·Radiation Research·S A MitchellE J Hall
Jan 14, 2009·Radiation Research·Torsten GroesserBjorn Rydberg
Jan 1, 2005·Nonlinearity in Biology, Toxicology, Medicine·J Leslie Redpath
Jun 15, 2016·International Journal of Cancer. Journal International Du Cancer·Guozi YangJiuwei Cui
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·M Carmen Hernandez, Susan J Knox
Aug 22, 2007·The International Journal of Biochemistry & Cell Biology·Rajamanickam BaskarM Prakash Hande
Apr 9, 2004·Human & Experimental Toxicology·Charles A Waldren
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Francesca Ballarini, Andrea Ottolenghi
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Jürgen Kiefer
Oct 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·H SchöllnbergerW Hofmann
Jul 25, 2006·Physics in Medicine and Biology·Regina BromleyClive Baldock

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