PMID: 2509375Jan 1, 1989Paper

Cellular communication in leukotriene C4 production between eosinophils and neutrophils

International Archives of Allergy and Applied Immunology
E KloproggeH F Kauffman

Abstract

Eosinophilic granulocytes as well as neutrophilic granulocytes produced leukotriene C4 (LTC4) on stimulation with 1 microM A23187 (Ca2+ ionophore). In healthy volunteers, the LTC4 production in eosinophils was about 3 times the production in neutrophils. Within 15 min greater than 90% of the LTC4 was released into the supernatant. Stimulation of eosinophils and neutrophils together resulted in a synergistic increase in LTC4 production of 306 +/- 40%. LTC4 synthesis by hypodense eosinophils was also enhanced if stimulated in the presence of neutrophils. These findings suggest a communication between eosinophils and neutrophils, which may play a role in bronchial asthma.

Citations

Oct 30, 1996·Journal of Immunological Methods·J B SedgwickW W Busse
Jan 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P R GrayM L Peters-Golden
Jan 1, 1991·Annals of the New York Academy of Sciences·T J WilliamsS Nourshargh
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SchuilingH Meurs

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