PMID: 9171158May 1, 1997Paper

Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease

Cell Transplantation
D F EmerichM D Lindner

Abstract

The delivery of ciliary neurotrophic factor (CNTF) to the central nervous system has recently been proposed as a potential means of halting or slowing the neural degeneration associated with Huntington's disease (HD). The following set of experiments examined, in detail, the ability of human CNTF (hCNTF) to prevent the onset of behavioral dysfunction in a rodent model of HD. A DHFR-based expression vector containing the hCNTF gene was transfected into a baby hamster kidney fibroblast cell line (BHK). Using a polymeric device, encapsulated BHK-control cells and those secreting hCNTF were transplanted bilaterally into rat lateral ventricles. Eight days later, the same animals received bilateral injections of quinolinic acid (QA, 225 nmol) into the previously implanted striata. A third group received sham surgery (incision only) and served as a normal control group. Bilateral infusions of QA produced a significant loss of body weight and mortality that was prevented by prior implantation with hCNTF-secreting cells. Moreover, QA produced a marked hyperactivity, an inability to use the forelimbs to retrieve food pellets in a staircase test, increased the latency of the rats to remove adhesive stimuli from their paws, and decreased t...Continue Reading

Citations

Dec 1, 2001·Expert Opinion on Biological Therapy·D F Emerich
Nov 13, 2004·Neuroreport·Cesario V BorlonganDwaine F Emerich
Sep 5, 2008·Neurological Research·Edalatmanesh Mohammad AminNeshati Zeinab
Oct 8, 2009·Journal of Drug Targeting·Sandra R Alcalá-BarrazaLinda K McLoon
May 21, 2009·Expert Opinion on Emerging Drugs·Sarah L Mason, Roger A Barker
Nov 17, 2006·Brain Pathology·Armin Blesch
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen B Dunnett, Anne E Rosser
Aug 16, 2000·Advanced Drug Delivery Reviews·P A TrescoM D Noble
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow

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