Jun 29, 2016

Cellular delivery of modified peptide nucleic acids: a review

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Chundong LiuFang Zeng

Abstract

Peptide nucleic acid (PNA) is a DNA surrogate in which the phosphate deoxyribose backbone of DNA is replaced by repeating N-(2-aminoethyl)glycine units. PNA can hybridize to the complementary DNA and RNA with higher affinity than their oligonucleotide counterparts. This character of PNA not only makes it a new tool for the studies of molecular biology but also the potential candidate for gene-targeting drugs. The non-ionic backbone of PNA leads to stable hybrids with the nucleic acids, but at the same time, the neutral backbone results in poor cellular uptake. To address this problem, studies on modified PNA progress rapidly in recent years. We reviewed literature reports combined with our study about the delivery methods, including backbone modified PNA and PNA-ligand conjugates, and the cellular uptake of modified PNA. In addition, we summarized the problems and future prospect of the cellular delivery of modified PNA.

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Mentioned in this Paper

Peptide Nucleic Acids
Study
Uptake
Phosphate Measurement
Glycine
Glycine (Plant)
Hybrids
Pharmacologic Substance
Oligonucleotides
DNA, Complementary

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