PMID: 9428932Jan 16, 1998Paper

Cellular distribution of c-Jun and c-Fos in rat lung before and after bleomycin induced injury

Virchows Archiv : an International Journal of Pathology
Michael G HaaseM Müller

Abstract

C-Jun and c-Fos transcription factors have been associated with enhanced cellular proliferation. We studied their cellular distribution in normal and fibrotic rat lung. Pulmonary fibrosis was induced by intratracheal administration of bleomycin. In normal rat lung, c-Jun and c-Fos are present in alveolar macrophages and type II pneumocytes, in the bronchiolar epithelium and in smooth muscle cells of bronchioli and blood vessels. Subcellular fractionation of proteins revealed a predominant presence of both c-Jun and c-Fos in the heavy membrane fraction containing mitochondria and secretory granules. This was confirmed by immunoelectron microscopy, which also revealed a different localization of c-Jun and c-Fos in different cell types. Whereas in type II pneumocytes and in macrophages cytoplasmic c-Jun and c-Fos is associated with mitochondria, in Clara cells of the bronchial epithelium only secretory granules contain c-Jun and c-Fos. In addition, c-Jun is strongly present in the nuclear fraction. In the fibrotic rat lung c-Jun and c-Fos are located in the same cell types as in control lungs. In addition, fibroblasts contain c-Jun and c-Fos in areas of proliferation whereas in areas of complete fibrosis there is only a very weak ...Continue Reading

Citations

Aug 17, 2000·Springer Seminars in Immunopathology·C FonsecaC M Black
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J S WeissteinT A Einhorn
Jan 29, 2005·American Journal of Respiratory Cell and Molecular Biology·Sylvain Marchand-AdamBruno Crestani
May 7, 2008·American Journal of Respiratory Cell and Molecular Biology·Serena FineschiCarlo Chizzolini
Dec 19, 2009·Journal of the American Society of Nephrology : JASN·Chun-Liang LinFeng-Sheng Wang
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·N KaminskiR A Heller
Sep 24, 2014·Genome Biology and Evolution·Amit BlumbergDan Mishmar
Aug 8, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michael G HaaseGustavo B Baretton
Oct 28, 2004·Experimental and Molecular Pathology·Renald BlundellDavid Harrison
Apr 13, 2013·International Journal of Radiation Biology·Michael G HaaseJörg Kotzerke
Jun 24, 2003·Neuron·Girish V PutchaEugene M Johnson
Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·W H ChungT E Massey
Dec 16, 2020·International Journal of Radiation Biology·Felicitas MayerMichael G Haase
Aug 28, 2021·International Journal of Molecular Sciences·Chiara RossiManuel Portero-Otin

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