PMID: 6172141Nov 1, 1981Paper

Cellular distribution of monoclonal antibody in human tumours after i.v. administration

British Journal of Cancer
V MoshakisA M Neville

Abstract

Immune-suppressed mice carrying xenografts of several different types of human germ-cell tumours were injected with a radiolabelled monoclonal antibody (LICR LON/HT13) raised against membrane components of a human germ-cell tumour (HX39). Subsequent assessment of radioactivity in excised organs and tumours showed a selective accretion of antibody in the tumour. Quantitative autoradiography supported the results of radiolocalization observed in vivo in different tumours, and also showed that the antibody localized to viable tumour cells and in close association with their cell membrane. The vascular architecture of tumours was found to be an important factor governing antibody distribution. No localization occurred with radiolabelled normal mouse IgG.

Citations

Jan 1, 1991·Annals of the New York Academy of Sciences·T R ShockleyM L Yarmush
Mar 1, 1985·Cancer·A A EpenetosJ S Malpas
Feb 1, 1987·British Journal of Obstetrics and Gynaecology·J H ShepherdM Slevin
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Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·M V PimmR W Baldwin
Nov 12, 1983·British Medical Journal·E M Rankin, J G McVie
Jan 1, 1988·British Journal of Neurosurgery·J BehnkeN De Tribolet
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Jan 1, 1984·Medical Oncology and Tumor Pharmacotherapy·R K OldhamK A Foon

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