PMID: 9181485Feb 1, 1997Paper

Cellular distribution of myosin-V in the guinea pig cochlea

Journal of Neurocytology
D E ColingB Kachar

Abstract

The importance of unconventional myosins to hearing has recently been revealed by the identification of myosins-VI and -VII as the defective genes in mouse mutations and in a human syndrome which lead to profound hearing loss. Another class of novel myosins (V) has been implicated in the trafficking of intracellular vesicles in neurons and other secretory cells. We used affinity-purified antibodies to determine the localization of myosin-V in the guinea pig inner ear. In the sensory epithelium of the cochlea, myosin-V epitopes were recognized in neuronal and supporting cells. Neuronal labelling was most intense in the afferent innervation of inner and outer hair cells. Supporting cells labelled were cells of Hensen and Deiters, and inner border, inner phalangeal, inner sulcus and interdental cells. In the vascular tissue of the cochlea, we observed staining of intermediate cells of the stria vascularis and of border cells between the stria and the spiral prominence. Staining of afferent chalice nerve endings was observed on type I vestibular hair cells. The results suggest that, like myosins VI and VII, myosin-V is localized in positions that may be critical to auditory function.

Citations

Nov 5, 2003·Journal of Neurobiology·Michael E Brown, Paul C Bridgman
Jan 20, 2006·Pigment Cell Research·Robert Tew Boyle, John Campbell McNamara
Aug 17, 2005·Audiology & Neuro-otology·Joseph P RochePaul Popper
Mar 9, 2012·Bioinformatics and Biology Insights·Divya P SyamaladeviR Sowdhamini
Sep 10, 2003·Molecular Biology of the Cell·Steven R Wylie, Peter D Chantler
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·E M EspreaficoB Kachar
Apr 14, 2004·Journal of Neuroscience Research·Anand N MhatreAnil K Lalwani
Jun 27, 2008·Journal of Proteome Research·Samson JamesdanielDonald E Coling
Oct 22, 2003·Neuroscience·C Q TilelliN Garcia-Cairasco
Nov 8, 2005·Journal of Neuroscience Methods·Nilza Cristina ButtowEvanilde Buzzo Romano

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