Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid

Transplantation
S EjiriM Kodama

Abstract

Warm ischemia of the graft from non-heart-beating donors is considered a risk factor for posttransplant graft dysfunction. The early administration of cytoprotective agents may help improve graft dysfunction. Four groups of 10 pigs each underwent orthotopic liver transplantation. Prostaglandin I2 analogue, OP-41483, was administered intraportally 30 min before warm ischemic insult in donors and after reperfusion in recipients in one group. In the other study group, additional intravenous tauroursodeoxycholic acid (TUDC) was given before the warm ischemic insult in donors and after reperfusion, then maintained continuously until postoperative day (POD) 7. Exposure of liver grafts to warm ischemia resulted in severe congestion with the disappearance of thrombomodulin (Tm) from the sinusoidal endothelial cells (SECs) and smooth muscle cells (SMCs) around biliary epithelial cells (BEpCs) 2 hr after reperfusion, followed by positive immunoreactivity of Tm in BEpCs with hyperbilirubinemia, which was related to high mortality. Combined administration of OP-41483 and TUDC had a protective effect, demonstrated by sustained immunoreactivity of Tm from SECs and SMCs until POD 7, without that reactivity in BEpCs. This was associated with r...Continue Reading

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IkedaK Sugimachi
Apr 1, 1995·The Journal of Pathology·D E JacksonJ A Hayman
Sep 1, 1994·American Journal of Hematology·G HimmelreichH Riess
Jan 1, 1993·Seminars in Thrombosis and Hemostasis·M RiewaldH Riess
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W GaoP A Clavien
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A Clavien
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeuersG Paumgartner
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P InvernizziM Podda

❮ Previous
Next ❯

Citations

Jan 5, 2010·Journal of Ocular Biology, Diseases, and Informatics·Jeffrey H BoatrightMachelle T Pardue
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Serban C StoicaStephen R Large
Jun 15, 2010·Biochemical and Biophysical Research Communications·Yeon Yi LeeKyong Soo Park
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Srikanth ReddyPeter Friend
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chengbin WangRichard A Kaslow
Jun 10, 2006·Experimental Dermatology·Metin ArtucBeate M Henz
Dec 14, 2011·Reproduction in Domestic Animals = Zuchthygiene·J-S KimD-B Koo
Jan 1, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gianfranco AlpiniGene LeSage
Oct 28, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Daisuke NoguchiShugo Mizuno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Constadina J AggeliWilliam A Zoghbi
Biochemical and Biophysical Research Communications
Akihiko OkamotoAkira Kakizuka
Transplant International : Official Journal of the European Society for Organ Transplantation
Grzegorz NowakBo-Göran Ericzon
© 2021 Meta ULC. All rights reserved