Abstract
Warm ischemia of the graft from non-heart-beating donors is considered a risk factor for posttransplant graft dysfunction. The early administration of cytoprotective agents may help improve graft dysfunction. Four groups of 10 pigs each underwent orthotopic liver transplantation. Prostaglandin I2 analogue, OP-41483, was administered intraportally 30 min before warm ischemic insult in donors and after reperfusion in recipients in one group. In the other study group, additional intravenous tauroursodeoxycholic acid (TUDC) was given before the warm ischemic insult in donors and after reperfusion, then maintained continuously until postoperative day (POD) 7. Exposure of liver grafts to warm ischemia resulted in severe congestion with the disappearance of thrombomodulin (Tm) from the sinusoidal endothelial cells (SECs) and smooth muscle cells (SMCs) around biliary epithelial cells (BEpCs) 2 hr after reperfusion, followed by positive immunoreactivity of Tm in BEpCs with hyperbilirubinemia, which was related to high mortality. Combined administration of OP-41483 and TUDC had a protective effect, demonstrated by sustained immunoreactivity of Tm from SECs and SMCs until POD 7, without that reactivity in BEpCs. This was associated with r...Continue Reading
References
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IkedaK Sugimachi
Sep 15, 1995·Transplantation·B SidoP P Nawroth
Apr 1, 1995·The Journal of Pathology·D E JacksonJ A Hayman
Oct 1, 1994·Annals of Medicine·A Stiehl
Sep 1, 1994·American Journal of Hematology·G HimmelreichH Riess
Jan 1, 1993·Seminars in Thrombosis and Hemostasis·M RiewaldH Riess
Jul 27, 1996·Transplantation·I TomitaS Kasai
Jan 1, 1997·Surgery Today·A KishidaM Kodama
Jan 15, 1998·Gastroenterology·S MotoyamaM Kitamura
Apr 16, 1998·Journal of Hepatology·C BenzA Stiehl
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W GaoP A Clavien
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A Clavien
Sep 3, 1998·European Journal of Clinical Investigation·C BenzA Stiehl
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeuersG Paumgartner
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P InvernizziM Podda
Citations
Jan 5, 2010·Journal of Ocular Biology, Diseases, and Informatics·Jeffrey H BoatrightMachelle T Pardue
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Serban C StoicaStephen R Large
Jul 31, 2009·PloS One·Ge ZhangLing Qin
Jun 15, 2010·Biochemical and Biophysical Research Communications·Yeon Yi LeeKyong Soo Park
Nov 23, 2006·Ultrasound in Medicine & Biology·James F ZacharyWilliam D O'Brien
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Srikanth ReddyPeter Friend
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chengbin WangRichard A Kaslow
Jun 10, 2006·Experimental Dermatology·Metin ArtucBeate M Henz
Dec 14, 2011·Reproduction in Domestic Animals = Zuchthygiene·J-S KimD-B Koo
May 5, 2016·Medical Hypotheses·Yilei DengXu Lu
Jan 28, 2015·BMC Physiology·Danielle L IppolitoJonathan D Stallings
Feb 22, 2003·Circulation Research·Scott W KlarenbachAllan G Murray
Jan 1, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gianfranco AlpiniGene LeSage
Oct 28, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Daisuke NoguchiShugo Mizuno