Cellular function and molecular structure of ecto-nucleotidases.

Purinergic Signalling
Herbert ZimmermannNorbert Sträter

Abstract

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generate extracellular nucleosides for cellular reuptake and salvage via nucleoside transporters of the plasma membrane. The extracellular adenosine formed acts as an agonist of purinergic P1 receptors. They also can produce and hydrolyze extracellular inorganic pyrophosphate that is of major relevance in the control of bone mineralization. This review discusses and compares four major groups of ecto-nucleotidases: the ecto-nucleoside triphosphate diphosphohydrolases, ecto-5'-nucleotidase, ecto-nucleotide pyrophosphatase/phosphodiesterases, and alkaline phosphatases. Only recently and based on crystal structures, detailed information regarding the spatial structures and catalytic mechanisms has become available for members of these four ecto-nucleotidase families. This permits detailed predictions of their catalytic mechanisms and a comparison between the individual enzyme groups. The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribu...Continue Reading

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Citations

Dec 12, 2012·Purinergic Signalling·Elisabet AliagasMireia Martín-Satué
Apr 3, 2013·Purinergic Signalling·Geoffrey Burnstock, Ivana Novak
Aug 15, 2013·Purinergic Signalling·Geoffrey BurnstockIsabel R Orriss
Jun 27, 2012·Journal of Medicinal Chemistry·Peter RipphausenJürgen Bajorath
May 15, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Katarzyna RoszekMichał Komoszyński
Nov 14, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Katarzyna RoszekMichał Komoszyński
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Jun 28, 2014·Journal of Medicinal Chemistry·Irina GillermanBilha Fischer
Jun 25, 2014·Autonomic Neuroscience : Basic & Clinical·L Camilo NavarreteJ Pablo Huidobro-Toro
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Apr 5, 2014·Acta Crystallographica. Section D, Biological Crystallography·Matthias ZebischNorbert Sträter
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