PMID: 1184239Nov 15, 1975Paper

Cellular immune reactivity in vitro and tumor rejection provided by tumor-associated antigens of friend-virus-induced leukemia

International Journal of Cancer. Journal International Du Cancer
J H DeanE Appella

Abstract

Cell-mediated immunity (CMI) and tumor rejection were studied in the Friend virus leukemia system of C57Bl/6 mice. Mice were immunized with Friend leukemia virus (FLV) or X-irradiated FBL-3 leukemic cells and studied temporally for the development of CMI reactivity by assays of 51Cr release lymphocyte cytotoxicity, lymphocyte transformation, migration inhibition, Winn tumor cell neutralization and transplantation rejection. High levels of specific lymphocyte cytotoxicity were observed by day 7 f0llowing FLV infection; this reactivity reached a peak between 17 and 21 days, and returned to background levels by day 36. Further, positive Winn assays were obtained with spleen cells from mice immunized with FLV at times when the mice resisted live FBL-3 tumor challenge. Positive lymphocyte transformation was obtained with spleen cells from mice immunized with FLV or FBL-3, but not with cells from normal mice or mice immune to a syngeneic methycholanthrene-induced tumor, when cultured with papain-soluble FBL-3 or RBL-5 tumor-cell extracts or mitomycin-C (MMC)-treated FBL-3 or RBL-5 cells. Positive reactivity in the lymphocyte transformation assay occurred after reactivity had peaked in the lymphocyte cytotoxicity test. Similar positiv...Continue Reading

References

Sep 15, 1975·International Journal of Cancer. Journal International Du Cancer·J H DeanL W Law
Jul 15, 1973·International Journal of Cancer. Journal International Du Cancer·A SenikJ P Levy
Nov 1, 1973·Journal of the National Cancer Institute·D H LavrinN Soares
Sep 15, 1969·International Journal of Cancer. Journal International Du Cancer·I Hellström, K E Hellström

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Citations

Jan 1, 1976·Annals of the New York Academy of Sciences·L W LawM Rogers

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