Cellular immune response and cytokine profile among hepatitis C positive living donor renal transplant recipients

Transplantation
S JustaV K Sakhuja

Abstract

Hepatitis C virus (HCV) infection is prevalent among renal transplant recipients. Twenty-five recipients of living donor renal transplantation with HCV (group I) and without HCV (group II) were serially monitored at three time points, that is, pretransplant, day 10, and 6 months posttransplant. Phenotypic characterization of T-cell subsets and natural killer cells was performed by flow cytometric immunophenotyping. Cytometric bead array immunoassay was used to simultaneously measure six cytokines (interleukin [IL]-2, IL-4, IL-5, IL-10, tumor necrosis factor-α, and interferon-γ) from phytohemagglutin-stimulated culture supernatants, and transforming growth factor (TGF)-β1 levels were determined by ELISA. Real-time polymerase chain reaction method was used to determine the serum viral load among group I patients at three time points. Group I patients on day 10 posttransplant showed a significant increase in T cells subsets with reduced interferon-γ and increased TGF-β1 levels. A significantly increased CD8 T cells and TGF-β levels were seen at 6-month posttransplant among group I patients. Multivariate linear regression analysis showed TGF-β and tumor necrosis factor-α as the most significant predictors affecting early (day 10) a...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J BukhR H Miller
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jan 4, 1998·Journal of Gastroenterology and Hepatology·Y T TsaiS D Lee
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Apr 8, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T M ChanK N Lai
Jun 17, 2000·Infection and Immunity·A J LutyP G Kremsner
Mar 27, 2001·Transplantation Proceedings·C FríasV Ausina
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FabriziC Ponticelli
Feb 22, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·D RatgeC Knabbe
May 16, 2002·Transplantation Proceedings·Yvoty Alves dos Santos SensP Jabur
Sep 11, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Einav, M J Koziel
Dec 21, 2002·Transplantation Proceedings·J N BoletisC Stavropoulos-Giokas
Mar 26, 2003·Journal of Gastroenterology and Hepatology·Sumar RayShobha Broor
Jun 27, 2003·Human Immunology·Domenico LioPiero L Almasio
Nov 25, 2003·Journal of Medical Virology·Hiroyoshi TaniguchiMasao Omata
Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Alejandro SchijmanJuan Cristina
Jun 25, 2005·Journal of Medical Virology·Nassim KamarJacques Izopet
Apr 14, 2006·Kidney International·P Pribylova-HribovaJ Lacha
Feb 28, 2007·Cytokine & Growth Factor Reviews·Leonardo FainboimLourdes Arruvito
Dec 18, 2007·Digestive Diseases and Sciences·Vikas VermaPremashis Kar
Jan 26, 2008·Clinical Transplantation·J ArangoC Aguirre
May 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cristina CostaRossana Cavallo
Jul 19, 2008·Digestive Diseases and Sciences·Paul Moayyedi
Sep 25, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M KoukoulakiS Drakopoulos
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shobha NarahariDhananjaya Saranath

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