PMID: 9537274Apr 16, 1998Paper

Cellular immune response of Mastomys and gerbils in experimental filariasis

Tropical Medicine & International Health : TM & IH
S MisraR K Chatterjee

Abstract

To determine mitogenic and antigen-specific cellular immune responses of two species of rodents, viz. Meriones unguiculatus and Mastomys coucha to assess the usefulness of the A. viteae/Mastomys model for cellular immune studies in experimental filariasis. Lymphocyte blast transformation test (LTT) using spleen cells of normal and A. viteae infected animals. The proliferative response of gerbils was much higher than that of Mastomys to both ConA and filarial antigens. Cells of both species of rodents did not respond to microfilarial (mf) antigen, however, their mitogenic response differed during infection. Some degree of nonspecific suppression was observed in gerbils during prepatent and patent stages of infection, while Mastomys revealed highest proliferation during patent microfilaraemia. Mastomys cells did not respond to adult or mf antigen, while adult-specific proliferation was detected in the case of gerbils. The A. viteae/gerbil model shows more similarity to human filarial infection regarding cellular immune response. Markedly low responsiveness of a high percentage of Mastomys and wide variations in the cellular response to nonspecific mitogen limit the usefulness of Mastomys coucha in immunological studies, especiall...Continue Reading

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A Dalesandro, T R Klei
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·H Fuglsang, J Anderson
Jul 15, 1982·The New England Journal of Medicine·W F PiessensW P Carney
Apr 10, 1980·The New England Journal of Medicine·W F PiessensD T Dennis

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Citations

Oct 20, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Jeetendra Kumar NagShailja Misra-Bhattacharya
Jul 9, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Nidhi ShrivastavaShailja Misra-Bhattacharya

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