Cellular immune response of patients with neurocysticercosis (inflammatory and non-inflammatory phases)

Acta Tropica
E C BuenoA J Vaz

Abstract

The cellular immune response in neurocysticercosis (NC) was studied in 22 patients, 11 (50%) of them in the inflammatory phase of the disease, by means of immunophenotyping of cells in cerebrospinal fluid (CSF) and peripheral blood (PB), lymphoproliferation assay with Taenia solium total saline extract (Tso) and Taenia crassiceps vesicular fluid (Tcra) as stimuli, and by determining the cytokine production profile in the cell culture supernatant. A higher mean percentage of CD19+ and CD56+ cells was observed in the CSF samples from inflammatory (16.8 and 11.3%) and non-inflammatory NC-patients (14.1 and 8.4%) when compared with the control group (CG, 7.6 and 5.4%). The CSF samples from inflammatory NC-patients also showed a higher percentage of HCAM (19.1%) and ICAM (44.9%) adhesion molecules when compared to CG (3.1 and 4.8%). The inflammatory phase showed predominance of CD8+ cells (CSF 26.6% and PB 36.2%) when compared with non-inflammatory phase (CSF 21.5% and PB 29.0%). All cell populations identified in the CSF from NC-patients showed cell activation (CD69+). The cell populations identified in PB showed higher expression of CD69 during the inflammatory phase, while only CD4+ cells presented no cell activation during the n...Continue Reading

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Citations

Jun 24, 2011·Medical Microbiology and Immunology·Brenda SáenzEdda Sciutto
Jun 7, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Anahí ChavarríaEdda Sciutto
Jul 19, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ulises RodríguezLuis A Herrera
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Aug 23, 2005·Memórias do Instituto Oswaldo Cruz·Ivanildes Solange da Costa BarcelosJulia Maria Costa-Cruz
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Dec 1, 2017·PLoS Neglected Tropical Diseases·Siddhartha MahantyUNKNOWN Cysticercosis Working Group in Peru
Apr 2, 2021·Expert Review of Anti-infective Therapy·Pedro T Hamamoto FilhoAgnès Fleury
Mar 20, 2019·World Neurosurgery·Pedro Tadao Hamamoto FilhoAgnès Fleury

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