PMID: 8592093Jan 1, 1996Paper

Cellular immune response to fractionated avian antigens by peripheral blood mononuclear cells from patients with pigeon breeder's disease

The Journal of Laboratory and Clinical Medicine
F MendozaM Selman

Abstract

Pigeon breeder's disease (PBD), a form of hypersensitivity pneumonitis caused by repeated inhalation of antigens of pigeon origin, is characterized by a diffuse inflammation of the lower respiratory tract. Although a variety of immunologic and nonimmunologic mechanisms have been described in the development of the disease, the pathogenesis is still far from clear. In this study we analyzed the T-lymphocyte proliferative response to a variety of avian antigens with use of peripheral blood mononuclear cells from 11 patients who had PBD and 10 healthy volunteers. We used a new method based on avian antigen-bearing nitrocellulose particles derived from Western blots to study the T-cell proliferative response to 15 antigenic fractions obtained from pigeon serum. With this technique, complex mixtures of antigens can be fractionated by polyacrylamide gel electrophoresis, transferred to nitrocellulose membranes, and used for T-cell proliferation assays with selected antigenic determinants. A wide variety of responses were observed, and there were no reproducible patterns of reaction within either group. Nine of 10 healthy subjects responded to some soluble fractions. However, patients with PBD displayed the strongest response and respo...Continue Reading

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Citations

Jul 9, 2002·Allergy·M Rosal-SanchezM Blanca
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Milton D RossmanDimitri Monos
May 3, 2014·Journal of Toxicology and Environmental Health. Part a·Adeline RouzetSandrine Roussel
Dec 30, 2014·Respiratory Investigation·Kozo SuharaNaohiko Inase
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C McSharryG Boyd
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J E CalvertS J Bourke
Aug 2, 2000·Pediatric Pulmonology·V GrechH Lenicker
Jul 15, 2004·Oncology Nursing Forum·Muriel J Montbriand
Apr 22, 2017·Respiratory Research·Tsuyoshi ShiraiNaohiko Inase

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