Cellular Immune Responses 6 Years Following 1, 2, or 3 Doses of Quadrivalent HPV Vaccine in Fijian Girls and Subsequent Responses to a Dose of Bivalent HPV Vaccine

Open Forum Infectious Diseases
Zheng Quan TohPaul V Licciardi

Abstract

This study examined the cellular immunity of 0, 1, 2, and 3 doses of Gardasil vaccine (4vHPV) in girls after 6 years and their responses to a subsequent dose of Cervarix vaccine (2vHPV). A subset of girls (n = 59) who previously received 0, 1, 2, or 3 doses of 4vHPV 6 years earlier were randomly selected from a cohort study of Fijian girls (age 15-19 years). Blood was collected before and 28 days after a dose of 2vHPV. The HPV16- and HPV18-specific cellular immune response was determined by IFNγ-ELISPOT and by measurement of cytokines in peripheral blood mononuclear cell supernatants. Six years after 4vHPV vaccination, HPV18-specific responses were significantly lower in the 1- (1D) or 2-dose (2D) recipients compared with 3-dose recipients (2D: IFNγ-ELISPOT: P = .008; cytokines, IFNγ: P = .002; IL-2: P = .022; TNFα: P = .016; IL-10: P = .018; 1D: IL-2: P = .031; IL-10: P = .014). These differences were no longer significant post-2vHPV. No significant differences in HPV16 responses (except IL-2, P < .05) were observed between the 2- or 1-dose recipients and 3-dose recipients. These data suggest that cellular immunity following reduced-dose schedules was detectable after 6 years, although the responses were variable between HPV t...Continue Reading

References

Dec 9, 2003·Journal of Immunological Methods·Annika C KarlssonElizabeth Sinclair
May 15, 2007·The New England Journal of Medicine·UNKNOWN FUTURE II Study Group
May 15, 2007·The New England Journal of Medicine·Suzanne M GarlandUNKNOWN Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators
Jun 29, 2007·Clinical and Vaccine Immunology : CVI·Alfonso García-PiñeresLigia A Pinto
May 2, 2013·JAMA : the Journal of the American Medical Association·Simon R M DobsonEric Young
Jan 24, 2014·Clinical Science·Ilja StrizAlena Sekerkova
Aug 20, 2014·Pediatrics·Daron FerrisAlfred Saah
May 13, 2015·Viral Immunology·Ana Katherine GonçalvesSteven S Witkin
Sep 28, 2017·Journal of the National Cancer Institute·Mahboobeh SafaeianUNKNOWN Costa Rica HPV Vaccine Trial (CVT) Group
Mar 20, 2018·Vaccine·Rengaswamy SankaranarayananUNKNOWN Indian HPV vaccine study group

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