PMID: 7024311Sep 1, 1981Paper

Cellular immune responses to extracellular streptococcal products in rheumatic heart disease

The Journal of Clinical Investigation
E D GrayZ H Abdin

Abstract

The lymphocyte transformation responses to purified preparations of two extracellular products of group A streptococci (blastogen A and nuclease B), to phytohemagglutinin, and to Candida albicans antigen were measured in tonsillar and peripheral blood lymphocytes from patients with rheumatic heart disease (RHD) and suitably matched nonrheumatic (control) subjects. The mean phytohemagglutinin dose responses of tonsillar and peripheral lymphocytes from RHD patients were essentially indistinguishable from those of controls. In contrast, the responses of tonsillar and peripheral blood lymphocytes to the two extracellular products of group A streptococci were significantly lower in RHD patients than in nonrheumatic control subjects. Candida antigen produced very little stimulation of lymphocytes in any of the subjects. The geometric means of antibody levels against streptolysin O, nuclease B, and nicotinamide adenine dinucleotidase showed no consistent differences between the control group and the group of RHD subjects. Group A streptococci were isolated from the tonsils of approximately 25% of both groups of subjects. The RHD patients clearly had a depressed cellular immune response to the two purified streptococcal extracellular a...Continue Reading

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·J E Parrillo, A S Fauci
Jan 1, 1979·Pediatric Research·N Meriç, A I Berkel
May 1, 1975·The Journal of Experimental Medicine·L J GreenbergE J Yunis
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Nov 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·K HIRSCHHORNR H GRUSKIN

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Citations

Sep 1, 1990·Indian Journal of Pediatrics·K S ReddyN K Mehra
Nov 1, 1982·Indian Journal of Pediatrics·K S ReddyM L Bhatia
Jun 1, 1986·The Journal of Clinical Investigation·E M AyoubJ P Krischer
Jul 1, 1982·Journal of Clinical Immunology·R C WilliamsK B Sharma
Nov 1, 1991·Clinical Immunology and Immunopathology·G H Stollerman

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