PMID: 10225908May 4, 1999Paper

Cellular immune responses to Neisseria meningitidis in children

Infection and Immunity
Andrew J PollardM Levin

Abstract

There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure of protection in older children but have been ineffective in infants. We postulated that the inability of OMP vaccines to protect infants might be due to age-dependent defects in cellular immunity. We measured proliferation and in vitro production of gamma interferon (IFN-gamma), tumor necrosis factor alpha, and interleukin-10 (IL-10) in response to meningococcal antigens by peripheral blood mononuclear cells (PBMCs) from children convalescing from meningococcal disease and from controls. After meningococcal infection, the balance of cytokine production by PBMCs from the youngest children was skewed towards a TH1 response (low IL-10/IFN-gamma ratio), while older children produced more TH2 cytokine (higher IL-10/IFN-gamma ratio). There was a trend to higher proliferative responses by PBMCs from older children. These responses were not influenced by the presence or subtype of class 1 (PorA) OMP or by the presence of class 2/3 (PorB) or class 4 OMP. Even young infants might be expected to develop adequate cellular immune responses to ...Continue Reading

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May 4, 1999·Infection and Immunity·A J PollardM Levin

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Citations

Dec 1, 2001·Expert Opinion on Biological Therapy·A Riddell, J Buttery
Sep 22, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gro TunheimEinar Rosenqvist
Jul 9, 2020·Pathogens and Disease·Gabriela Trzewikoswki de LimaElizabeth De Gaspari
Dec 19, 2001·Infection and Immunity·Anastasios TsirpouchtsidisGaby Haas
Feb 21, 2002·Infection and Immunity·K RobinsonD A A Ala'Aldeen
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria DavenportRobert S Heyderman
Dec 15, 2006·Cellular Microbiology·Victoria DavenportRobert S Heyderman
May 18, 2007·Journal of Clinical Laboratory Analysis·C T PercianiM M Tanizaki
Jul 26, 2005·Infection and Immunity·Karen RobinsonDlawer A A Ala'Aldeen
Oct 17, 2002·FEMS Immunology and Medical Microbiology·Clementien Vermont, Germie van den Dobbelsteen
Feb 13, 2001·Vaccine·A J Pollard, C Frasch

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