Cellular immune responses to ovalbumin and house dust mite in egg-allergic children

Allergy
T-W NgS L Prescott

Abstract

Although IgE-mediated food (egg) allergy is typically lost with age the underlying immune mechanisms are not understood, particularly in relation to the development of persistent IgE-mediated aeroallergen sensitivity. Lymphoproliferation and cytokine responses (IL-5, IL-10, IL-13 and IFN-gamma) to house dust mite (HDM) allergen and egg ovalbumin (OVA) were assessed using peripheral blood mononuclear cells (PBMC) from children aged 6 months to 5 years (n = 59) with acute IgE-mediated egg allergy (urticaria and angiedema or anaphylaxis), as confirmed by positive skin prick testing (SPT). Of these 46 had positive SPT on the day of blood collection and 13 had outgrown egg allergy (negative SPT and successful egg challenge). Where possible, responses were compared with previous data from nonallergic children of similar ages (n = 107). Transient lymphoproliferative responses to OVA were seen in both egg-allergic and nonallergic children, but were more marked and more prolonged in egg-allergic children. Younger egg-allergic children (< 18 months) showed a mixed Th0 cytokine response to OVA, with readily detectable IFN-gamma, IL-5, IL-13 IL-10. Although IL-13 and IL-5 responses (OVA) correlated in younger egg-allergic children, there w...Continue Reading

References

Dec 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G HoltW R Thomas
Jan 1, 1985·International Archives of Allergy and Applied Immunology·J AnetM E Howden
May 1, 1983·The Journal of Allergy and Clinical Immunology·D R Hoffman
Jan 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·R L BergmannJ Schulz
Oct 1, 1994·The Journal of Allergy and Clinical Immunology·N SigursB Björkstén
Jul 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W UphamP N Le Souef
Apr 1, 1996·International Archives of Allergy and Immunology·T KatsukiH Niimi
Jul 1, 1996·The Journal of Experimental Medicine·H GrouxM G Roncarolo
Feb 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P A EigenmannH A Sampson
Nov 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T NomaM Baba
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·H A Sampson
Aug 1, 1997·The Journal of Allergy and Clinical Immunology·A UrisuT Wakamatsu
Apr 3, 1998·The Journal of Allergy and Clinical Immunology·L Borish
Jul 25, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D E CampbellA S Kemp
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KuligU Wahn
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S L PrescottP G Holt
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P E EysinkR C Aalberse
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MacaubasP G Holt
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M P LaanH J Neijens
Jun 20, 2000·Allergy·C A Akdis, K Blaser
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force

❮ Previous
Next ❯

Citations

Dec 19, 2003·Current Allergy and Asthma Reports·Abbas Khakoo, Gideon Lack
Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Susan L Prescott
Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Aderbal SabraSelma Sabra
Nov 25, 2003·Journal of Paediatrics and Child Health·S L Prescott
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Susan L Prescott, Philip C Calder
May 18, 2005·International Archives of Allergy and Immunology·Mitsuaki Kimura, Makiko Obi
Feb 25, 2011·International Archives of Allergy and Immunology·Ian N GlaspoleJennifer M Rolland
Aug 23, 2011·Pediatric Research·Immacolata VoccaCarmen Gianfrani
Nov 1, 2005·Expert Review of Clinical Immunology·Mark A Aronica, Nicola Vogel
Aug 13, 2008·Expert Opinion on Biological Therapy·Christophe P Frossard, Philippe A Eigenmann
Aug 8, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J R MetcalfeD J Palmer
Jan 17, 2012·Immunology and Allergy Clinics of North America·Kirsi M Järvinen, David M Fleischer
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Jonathan D de JongeHenk van Loveren
Aug 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A DunstanS L Prescott
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F van WijkL M J Knippels
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S L PrescottJ W Upham
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S L PrescottP Richmond
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A DunstanS L Prescott
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert J BoyleMimi L K Tang
Apr 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A DunstanS L Prescott
Apr 3, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Antonella MuraroRobert S Zeiger
Feb 7, 2004·Allergy·J BousquetM Humbert
Sep 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S S TayP W Ewan
Jun 1, 2006·Clinical and Experimental Immunology·A-K LarssonM Troye-Blomberg
Mar 15, 2012·Allergy·I Lehmann, G Herberth
Feb 22, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susan Prescott, Katrina J Allen
Jan 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Vazquez-OrtizA M Plaza
Aug 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C PerrierB Corthésy
Feb 15, 2005·Pulmonary Pharmacology & Therapeutics·Susan L Prescott, Janet A Dunstan
Oct 21, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jenna C PodjasekYoung J Juhn
May 4, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laura PerezábadIván López-Expósito
Sep 18, 2010·FEMS Immunology and Medical Microbiology·Juan HuangBing Chen
May 8, 2004·The Journal of Allergy and Clinical Immunology·Machteld M TiemessenEls Van Hoffen
May 8, 2004·Free Radical Research·Anne E BardenSusan L Prescott
May 3, 2005·Current Opinion in Allergy and Clinical Immunology·Janet A Dunstan, Susan L Prescott
May 17, 2003·Current Opinion in Allergy and Clinical Immunology·Susan L Prescott
Jul 4, 2003·Current Opinion in Allergy and Clinical Immunology·Philippe A Eigenmann, Christophe P Frossard
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiangfeng SunManel Jordana
Aug 19, 2018·Nature Communications·David MartinoRichard Saffery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
J M Smart, A S Kemp
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
S S TayP W Ewan
International Archives of Allergy and Immunology
M Fagerås BöttcherB Björkstén
© 2022 Meta ULC. All rights reserved