PMID: 8877Jan 1, 1976

Cellular immunity against bacteria (intracellular and extracellular parasites) in experimentally aged rats (author's transl)

ZfA. Zeitschrift Für Alternsforschung
E JanevH Taskov

Abstract

The authors study the activity of RES in rats with Progeria-like syndrome of Selye, at the occasion of a repeated infection with bacteria--intracellular parasites (Brucella abortus 19) and bacteria--extracellular parasites (Diplococcus pneumoniae). They establish that immunization improves the activity of RES of the experimentally aged rats; still, its phagocytic and digestive functions remain by far feebler than those of the rats unsubjected to experimental ageing. By the aged animals the RES insufficiency is more pronounced towards the intracellular bacterium Brucella abortus 19, than towards the extracellular Diplococcus pneumoniae.

Related Concepts

Senility
Antigens, Bacterial
Brucella abortus bacterium
Cellular Immune Response
Revaccination
Liver
Lung
Phagocytosis
Progeria
Reticuloendothelial System

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