Cellular immunity and hypersensitivity as components of periodontal destruction

Oral Diseases
G J SeymourK Hara

Abstract

Cellular immunity has been implicated in periodontal destruction for over 25 years. Studies in the 1970s used lymphocyte transformation and lymphokine assays to establish a role for cell-mediated mechanisms in periodontal disease. Immunohistological studies subsequently showed that the formation of gingivitis followed a similar pattern to the formation of a delayed type hypersensitivity reaction. Further functional studies suggested that a T cell/macrophage immunoregulatory imbalance may exist locally in the periodontitis lesion and that this imbalance may be antigen specific. RECENT EVIDENCE: More recently, T cell subsets have been dichotomised on the basis of their cytokine profiles. In general, ThI cells produce IL-2 and IFN-gamma while Th2 cells produce IL-4, IL-5 and IL-6. The major function of Th1 cells is to mediate delayed type hypersensitivity. In contrast the major function of Th2 cells is to provide B cell help. A model for periodontal disease has now been developed based on this functional dichotomy which provides a framework for the study of cytokine profiles in periodontal disease. Early studies in this context have demonstrated a higher proportion of IL-4 producing cells in periodontitis tissues suggesting a role...Continue Reading

References

Jan 1, 1977·Journal of Periodontal Research·B F MacklerB M Levy
Jan 1, 1979·Journal of Periodontal Research·G J Seymour, J S Greenspan
Sep 1, 1978·Infection and Immunity·S A Syed, W J Loesche
Aug 1, 1992·Oral Microbiology and Immunology·T IshiiG J Seymour
Jun 1, 1992·Current Opinion in Immunology·R de Waal MalefytJ E de Vries
Nov 1, 1992·Immunology Today·F E Cox, F Y Liew
Apr 1, 1992·Immunology Today·B R BloomB Diamond
Oct 1, 1991·Immunology Today·P Scott, S H Kaufmann
Feb 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N E Street, T R Mosmann
Jun 1, 1991·Current Opinion in Immunology·T R Mosmann
Feb 1, 1990·Clinical and Experimental Immunology·P A Campbell
Mar 1, 1986·Journal of Periodontal Research·A C JohannessenT Kristoffersen
Mar 1, 1988·Oral Microbiology and Immunology·S S SocranskyJ D Hillman
Nov 1, 1986·Journal of Periodontology·S E WynneR N Powell
Nov 1, 1984·Journal of Periodontal Research·M A TaubmanD J Smith
Dec 1, 1982·Cellular Immunology·L W PoulterG Panayi
Nov 1, 1993·Journal of Periodontal Research·G J SeymourM A Taubman
Jan 1, 1994·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·E Gemmell, G J Seymour
Aug 1, 1995·Immunology Today·A Kelso
Sep 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K YamazakiK Hara
Sep 1, 1994·Journal of Periodontology·S S ManhartT M Petro
Jul 1, 1993·Immunology Today·G Trinchieri
Jun 1, 1993·Immunology Today·F Powrie, R L Coffman
Aug 1, 1993·Current Opinion in Immunology·R L Modlin, T B Nutman
Jun 1, 1994·Periodontology 2000·J L Ebersole, M A Taubman

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Citations

May 19, 2005·Journal of Periodontology·R B Johnson, F G Serio
Nov 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Woon-Hae KimKwan-Kyu Park
Aug 10, 1999·Journal of Periodontology·L A RozlogR Glaser
Jan 1, 1999·Oral Microbiology and Immunology·E GemmellG J Seymour
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Frans SluyterAlexander Cools
Jul 9, 2004·Community Dentistry and Oral Epidemiology·Vibeke Baelum, Rodrigo Lopez
Oct 23, 2002·Journal of Clinical Periodontology·Tord BerglundhJan Lindhe
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Okada, S Murakami
May 1, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S D EllisR B Johnson
Jul 27, 2010·Journal of Clinical Periodontology·Gaudy L Torres de HeensUbele van der Velden
Dec 23, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hsein-Kun LuMing-Fang Wu
May 4, 2007·Periodontology 2000·Lakshmi Boyapati, Hom-Lay Wang
Apr 6, 2016·Periodontology 2000·Ellie T KnightMary P Cullinan
May 21, 2014·Dental Update·Rajkumar Parwani, Simran R Parwani
Aug 8, 2009·Journal of Clinical Periodontology·Naila F P OliveiraAna Paula de Souza
Mar 26, 2003·Oral Microbiology and Immunology·M SabetiJ Slots
Feb 11, 2000·Archives of Oral Biology·T NakajimaG J Seymour

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