PMID: 6978082Jan 1, 1981Paper

Cellular immunity during pregnancy. II. Response to T and B cell mitogens

American Journal of Reproductive Immunology : AJRI
S R Gottesman, O Stutman

Abstract

Immune reactivity of primiparous pregnant C57Bl/6J mice was investigated using in vitro assays of mitogen reactivity. The response to the T cell mitogens phytohemagglutinin (PHA) and concanavalin A of cells from the paraaortic (PA) lymph nodes, which drain the uterus, was decreased in pregnant animals. Reactivity to lipopolysaccharide, a B cell mitogen, was normal. The decreased PHA response was seen with PA cells from mice bearing syngeneic or allogeneic (to DBA/2J) fetuses. It was not due to a change in sensitivity to PHA dose or to active suppression (as demonstrated by mixing experiments). Phytohemagglutinin reactivity of cells from inguinal nodes of pregnant mice showed a more variable depression of response in comparison to that seen with cells from the draining PA nodes. The response of axillary and brachial node cells was similar to virgin values. Statistical analysis revealed no differences in the average number of PA lymphocytes or fetuses per mouse between mice bearing syngeneic or allogeneic fetuses. This parallels the similarities found between syngeneic and allogeneic matings in in vitro functional assays. This study demonstrates that pregnant mice (syngeneic or allogeneic) show only a decrease in T proliferative ...Continue Reading

References

Oct 1, 1977·The Journal of Experimental Medicine·C G WebbG M Edelman
Jan 1, 1978·Journal of Reproduction and Fertility·C M Hetherington, H Fowler
May 1, 1977·Transplantation·M S Hamilton, I Hellström
Aug 1, 1977·Journal of Immunogenetics·C M Hetherington, D P Humber
Jan 1, 1971·Advances in Immunology·A E Beer, R E Billingham
Jun 1, 1971·Journal of Reproduction and Fertility·C M Hetherington
Jan 1, 1980·American Journal of Reproductive Immunology : AJRI·S R Gottesman, O Stutman

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Citations

Jun 1, 1990·Journal of Reproductive Immunology·S Kamel, G W Wood
May 1, 1990·American Journal of Reproductive Immunology : AJRI·L R BissetJ F Griffin
Feb 1, 1994·Kidney International·C PeterssonC Svanborg
Jul 1, 1989·American Journal of Reproductive Immunology : AJRI·I BhattacharyyaM Chowdhury

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