Cellular Immunotherapy for Hematologic Malignancies: Beyond Bone Marrow Transplantation

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Melita CirilloCatherine Cole

Abstract

Immunotherapy has changed treatment practices for many hematologic malignancies. Even in the current era of targeted therapy, chemotherapy remains the backbone of treatment for many hematologic malignancies, especially in acute leukemias, where relapse remains the major cause of mortality. Application of novel immunotherapies in hematology attempts to harness the killing power of the immune system against leukemia and lymphoma. Cellular immunotherapy is evolving rapidly for high-risk hematologic disorders. Recent advances include chimeric antigen-receptor T cells, mesenchymal stromal/stem cells, dendritic cell tumor vaccines, cytokine-induced killer cells, and virus-specific T cells. The advantages of nontransplantation cellular immunotherapy include suitability for patients for whom transplantation has failed or is contraindicated, and a potentially less-toxic treatment alternative to transplantation for relapsed/refractory patients. This review examines those emerging cellular immunotherapies that are changing treatment paradigms for patients with hematologic malignancies.

Citations

Jan 15, 2020·Bone Marrow Transplantation·Gonzalo Gutiérrez-GarcíaFrancesc Fernández-Avilés
Nov 21, 2020·International Journal of Molecular Sciences·Wen-Ying LinYi-Yen Lee
Sep 6, 2020·Cancer Treatment Reviews·Konstantinos VenetisNicola Fusco
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
May 15, 2021·Journal for Immunotherapy of Cancer·Lorenzo IovinoJoshua A Hill

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