Cellular inflammatory response associated with breakdown of the blood-brain barrier after closed head injury in rats

Journal of Neurotrauma
J LuE A Ling

Abstract

This study reports a widespread microglial response characterized by an upregulation of surface antigens, such as complement type 3 receptors (CR3) and major histocompatibility complex (MHC) class II antigens on these cells following closed head injury. Increased expression of CR3 (OX-42) and MHC class II antigens (OX-6) was observed in rats killed at 1, 3, and 5 days after injury. Intense OX-42 immunoreactivity was observed in microglial cells throughout the brain with a smaller number of them being OX-6 positive. In addition to microglial reaction, astrocytic activation reflected in cellular hypertrophy and increased immunoreactivity for glial fibrillary acidic protein (GFAP) was observed at 5 days after head injury. Together with the above, a diffuse perivascular and intraneuronal immunostaining for immunoglobulin G (IgG) was observed primarily in the cerebral cortex. This was accompanied by an enhanced expression of both endothelial nitric oxide synthase (eNOS) in blood vessels and inducible nitric oxide synthase (iNOS) in brain macrophages. In rats subjected to closed head injury followed by a single intraperitoneal (i.p.) injection of rhodamine isothiocyanate (RhIc), seepage of the fluorescent dye into the neuropil was ob...Continue Reading

References

Dec 1, 1991·Journal of Neuroimmunology·T Morioka, W J Streit
Jan 1, 1988·Glia·W J StreitG W Kreutzberg
Aug 1, 1986·The Journal of Experimental Medicine·D GiulianL B Lachman
Jan 1, 1987·Acta Neuropathologica·I Klatzo
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
Apr 1, 1994·Brain Research. Molecular Brain Research·M ButtiniH W Boddeke
Sep 1, 1994·Circulation Research·D JanigroH R Winn
Feb 1, 1994·Journal of Neurosurgery·A MarmarouK Demetriadou
Jan 1, 1993·Glia·P L McGeerE G McGeer
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Jan 20, 1997·The Journal of Comparative Neurology·P G PopovichB T Stokes
May 30, 1998·Journal of Neurotrauma·M M FolkertsJ A Rafols
Jan 15, 2000·Advances in Experimental Medicine and Biology·L Schilling, M Wahl
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D C HooperS V Spitsin

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Citations

Jun 25, 2003·Experimental Neurology·S ChenN G Harris
Aug 24, 2004·International Journal of Obstetric Anesthesia·B Mazul SunkoA Gopcević
Dec 20, 2002·Journal of Neurotrauma·José Miguel VelaBernardo Castellano
Oct 28, 2003·Journal of Neurotrauma·Douglas S DeWitt, Donald S Prough
Sep 11, 2012·Brain : a Journal of Neurology·Paula Fernandez-VizarraCarmen Gomez-Guerrero
Nov 5, 2014·Neural Regeneration Research·Long ZhouYigang Yu
Feb 26, 2009·Free Radical Research·Pamela B L PunShabbir Moochhala
Sep 27, 2014·Neurobiology of Disease·Xiaodi ChenBarbara S Stonestreet
Dec 14, 2011·Advanced Drug Delivery Reviews·Yan Chen, Lihong Liu
Dec 1, 2009·Neurosurgery Clinics of North America·Gurvinder KaurCourtney Crane
Nov 21, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Isaac YangAndrew T Parsa
Nov 10, 2007·Neuropathology and Applied Neurobiology·J E SimpsonUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
Dec 19, 2014·Brain Pathology·Stephen B WhartonPaul G Ince
May 26, 2005·Brain Research. Brain Research Reviews·Constantin BourasPanteleimon Giannakopoulos
Aug 28, 2004·Neuroscience Letters·Lingyun ZhuAnthony F Purchio
Aug 18, 2004·Neuroscience·D W HamptonJ W Fawcett
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Håkan Aldskogius
Feb 1, 2012·Brain Research Bulletin·Enci Mary KanJia Lu
Sep 6, 2014·Frontiers in Neuroscience·James P FullerJessica L Teeling
Oct 21, 2005·Journal of Neuroscience Research·Ya-Fen Jiang-ShiehChing-Hsiang Wu
Aug 28, 2012·The Journal of Trauma and Acute Care Surgery·Judith BellapartJohn Fraser
Feb 10, 2018·Frontiers in Immunology·Ying Fu, Yaping Yan
Jan 22, 2019·Journal of Neurotrauma·Colleen N BodnarAdam D Bachstetter
Sep 25, 2015·Current Opinion in Neurology·Roshini Prakash, S Thomas Carmichael
Mar 9, 2021·Frontiers in Immunology·Laura N VerboonAndrew D Greenhalgh

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