Cellular inflammatory responses: novel insights for obesity and insulin resistance

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Hong Chen

Abstract

Type 2 diabetes is rapidly becoming a worldwide epidemic. Obesity and sedentary lifestyle are the main environmental causes for the development of insulin resistance and type 2 diabetes. In the past decade, it has been increasingly recognized that obesity and insulin resistance are associated with chronic, low-grade systemic inflammation. This review will cover the recent advances in this field and provide a working model explaining how cellular inflammatory responses arise to cope with obesity-induced metabolic stresses and how these inflammatory responses underlie insulin resistance.

References

Jul 24, 1987·Science·J S FlierB M Spiegelman
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Jun 1, 1995·The Journal of Clinical Investigation·R V ConsidineJ F Caro
Oct 30, 1998·Diabetologia·J C Pickup, M A Crook
Jan 7, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H HaunerF Hube
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
Jan 5, 2000·Journal of Diabetes and Its Complications·M Rodríguez-Morán, F Guerrero-Romero
Nov 9, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F ArnalichC Montiel
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Aug 8, 2001·The Journal of Clinical Investigation·J K KimG I Shulman
Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Katherine EspositoDario Giugliano
Sep 14, 2002·The Journal of Biological Chemistry·Liangyou RuiMorris F White
Oct 9, 2002·Journal of Internal Medicine·G J Blake, P M Ridker
Nov 8, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·M LechleitnerA Dzien
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Jan 10, 2003·The Journal of Biological Chemistry·Guillaume CharrièreLouis Casteilla
Mar 12, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P W ConnellyB Zinman
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T SkurkH Hauner
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Katherine EspositoDario Giugliano

❮ Previous
Next ❯

Citations

Jul 30, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Hany M El-BassossyMona F Mahmoud
Jan 25, 2012·Cell Biochemistry and Biophysics·Jin-Gai ZhuXi-Rong Guo
Jul 27, 2007·Journal of Medicinal Food·Sarah Rachel KatzEphraim Philip Lansky
Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Arti ShahMuredach P Reilly
Jul 4, 2012·Journal of Translational Medicine·Tzu-Hsien TsaiHon-Kan Yip
Jan 22, 2010·The Journal of Clinical Endocrinology and Metabolism·Gregorio ChazenbalkRicardo Azziz
Jul 5, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·M Ethier-ChiassonJ Lafond
Dec 8, 2006·Annals of the New York Academy of Sciences·Krystallenia AlexandrakiAnastasios Kalofoutis
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Gabriel PascualAndrea L Hevener
Jul 22, 2014·Toxicology Mechanisms and Methods·Hany M El-BassossyAhmed Fahmy
Jan 20, 2015·Journal of Medicinal Food·Ana Laura de la GarzaFermín I Milagro
Jun 22, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano BellostaAlberto Corsini
Jan 14, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hung-Tsung WuJuei-Tang Cheng
Jun 27, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Anna-Maija TolppanenUNKNOWN Finnish Diabetes Prevention Study Group
Oct 11, 2017·Psychosomatic Medicine·Mary de GrootUNKNOWN Diabetes Prevention Program Research Group
Jun 29, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Roohollah MohseniMaryam Razzaghy Azar
Sep 19, 2019·Scientific Reports·Méndez-Martínez MarisolRosas Gabriela
May 3, 2014·International Journal of Molecular Medicine·Changchun CaoXin Chen
Jan 2, 2009·Pediatrics·Christel Evellen van Dijk, Sheila Margaret Innis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

The New England Journal of Medicine
R Ross
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
A De LorenzoL Di Renzo
American Journal of Human Genetics
Chuanhui DongR Arlen Price
Trends in Endocrinology and Metabolism : TEM
Rexford S Ahima
© 2022 Meta ULC. All rights reserved