PMID: 6969401Oct 1, 1980Paper

Cellular interactions in the generation of cytolytic T lymphocyte responses: role of Ia-positive splenic adherent cells in presentation in H-2 antigen

Proceedings of the National Academy of Sciences of the United States of America
O WeinbergerS J Burakoff

Abstract

Splenic adherent cells are required for generation of both primary and, at limiting antigen dose, secondary allogeneic responses of cytolytic T lymphocytes to intact stimulator cells. Secondary responses to purified allogeneic plasma membranes or purified H-2Kk antigens in liposomes are also dependent upon splenic adherent cells. Generation of these responses requires the presence of an Ia-positive. Thy 1,2-negative, radiation-resistant cell in the splenic adherent cell population that is adherent to glass, plastic, and nylon wool. Stimulation of cytolytic T lymphocyte precursors with purified H-2Kk alloantigen bound to Ia+ splenic adherent cells is 10-20 times more efficient than stimulation with antigen added directly to culture. Furthermore, a marked decrease in the response of cytolytic T lymphocytes to liposomes was observed when antiserum against Iad specific for the Ia of the responder cells was added to culture. These results demonstrate that, for purified proteins of the major histocompatibility complex, antigen presentation by Ia+ splenic adherent cells plays a role in the generation of a cytolytic T lymphocyte response.

References

Dec 1, 1978·The Journal of Experimental Medicine·R FinbergS J Burakoff
Mar 1, 1978·The Journal of Experimental Medicine·M MescherS Burakoff
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S J BurakoffB Benacerrah
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg

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Citations

Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·P Erb
Apr 1, 1987·Journal of the American Academy of Dermatology·A KohchiyamaH Ueki
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ingrid C RulifsonJeffrey A Bluestone
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·O WeinbergerS J Burakoff
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S H Herrmann, M F Mescher
Jun 1, 1982·The Journal of Experimental Medicine·D H Raulet, M J Bevan
May 1, 1983·The Journal of Experimental Medicine·D Bellgrau
Dec 1, 1984·The Journal of Clinical Investigation·P D SmithS M Wahl
Jan 1, 1996·International Reviews of Immunology·J A Bradley
Feb 1, 1994·Experimental Dermatology·L KeményT Ruzicka
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·S H Herrmann, M F Mescher
Dec 1, 1985·European Journal of Immunology·A Guimezanes, A M Schmitt-Verhulst
Sep 1, 1993·European Journal of Immunology·G Stuhler, P Walden

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