Cellular ions in NIDDM: relation of calcium to hyperglycemia and cardiac mass

Diabetes Care
M BarbagalloL M Resnick

Abstract

To investigate the role of hyperglycemia in mediating the clinical association of NIDDM with hypertension and left ventricular dysfunction and hypertrophy. Since hyperglycemia elevates cytosolic free calcium (Cai) both in myocardial and vascular smooth muscle cells, we utilized nuclear magnetic resonance (NMR) spectroscopy to measure erythrocyte Cai levels and compared them with serum ionized calcium (Caio), glucose, and insulin values before and following an oral glucose tolerance test (OGTT) and with previously obtained cardiac structural indexes in normotensive and hypertensive NIDDM (n = 32) and normal control subjects (n = 35). Compared with control subjects, normotensive NIDDM subjects had higher Cai (31.5 +/- 2.3 vs. 24.3 +/- 1.9 nmol/l, P = 0.05), lower intracellular free magnesium (Mgi) (200 +/- 10 vs. 225 +/- 7 mumol/l, P = 0.05), and greater posterior wall thickness (0.98 +/- 0.04 vs. 0.86 +/- 0.03 cm, P = 0.05). Hypertensive NIDDM subjects exhibited a further increase in Cai (43.1 +/- 4.4 nmol/l, P = 0.05 vs. control subjects) and left ventricular mass (LVM) (201.5 +/- 12.2 vs. 155.8 +/- 7.7 g, P = 0.05 vs. control subjects). For all subjects, significant relationships were observed between Cai and fasting blood glu...Continue Reading

Citations

Mar 5, 2004·International Journal of Cardiology·Franz C AepfelbacherAndrew J Burger
Jan 23, 2003·Molecular Aspects of Medicine·Mario BarbagalloGiuseppe Paolisso
Jan 23, 2003·Molecular Aspects of Medicine·Pietro Delva
May 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Domingo Hernández
Aug 2, 2007·American Journal of Therapeutics·Mario BarbagalloLawrence M Resnick
Jul 11, 2006·International Heart Journal·H Asuman KaftanMustafa Kilic
Jan 31, 2002·Drugs·Steven J Lavine, Steven D Gellman
Mar 19, 2005·Clinical and Experimental Hypertension : CHE·William WeglickiLarry Resnick
Jan 17, 2009·International Journal of Cardiology·Hitoshi IchikiChuwa Tei
Jul 1, 2006·Archives of Biochemistry and Biophysics·Mario Barbagallo, Ligia J Dominguez
Oct 3, 1999·Progress in Cardiovascular Diseases·L Resnick
Sep 13, 2000·Journal of the American Geriatrics Society·M BarbagalloL M Resnick
Jan 22, 2013·Biophysical Journal·Michele F M SciaccaCarmelo La Rosa
Sep 22, 2001·Hypertension·M BarbagalloL M Resnick
Jun 13, 2020·Frontiers in Endocrinology·Miguel Martin-Aragon BaudelManuel F Navedo
Jan 31, 2021·Biomedicines·Jorge SimónMaria Luz Martínez-Chantar

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