Abstract
The cellular kinetics of villous columnar epithelial cells and M cells in the rabbit small intestine were determined by the use of 5-bromo-2'-deoxyuridine (BrdU) as a tracer. To identify M cells, vimentin antibody was used. The BrdU-labeled nuclei of columnar epithelial cells reached the base of intestinal villi in all portions at 1 day after BrdU administration. Thereafter, BrdU-labeled cells migrated toward the villous tip, but they did not move at a uniform speed. The epithelial cells which existed in intestinal villi on circular folds moved faster than those on mucosa other than circular folds. At 7 days after BrdU administration, the leading edge of BrdU-labeled epithelial cells already disappeared from the villous tip in all portions of the small intestine. In the ileal Peyer's patch, the BrdU-labeled nuclei of microvillous epithelial cells and vimentin-positive M cells appeared near the intestinal crypt orifice at 1 day after BrdU administration, and then migrated toward the luminal surface of the follicle-associated epithelium (FAE). As they moved toward the upper portion of FAE, the number of BrdU-labeled M cells on the side of the dome decreased simultaneously. The leading edge of BrdU-labeled epithelial cells disappe...Continue Reading
References
Aug 1, 1992·Cell and Tissue Research·A GebertH Bartels
Mar 1, 1992·Experimental Physiology·M W Smith, M A Peacock
Mar 1, 1986·Gastroenterology·P SicińskiW Bem
May 1, 1971·The American Journal of Anatomy·W W Chang, C P Leblond
Dec 1, 1974·The American Journal of Anatomy·H Cheng, C P Leblond
Oct 1, 1980·The American Journal of Anatomy·M W Smith, M A Peacock
May 1, 1994·Scandinavian Journal of Gastroenterology·M AlamA Uribe
Dec 1, 1993·Histochemistry·M A JepsonB H Hirst
Jul 1, 1993·Cell and Tissue Research·M A JepsonB H Hirst
Jan 1, 1996·International Review of Cytology·A GebertR Pabst
Aug 1, 1996·Trends in Microbiology·T C Savidge
Nov 25, 1998·Journal of Anatomy·T TakeuchiM Uehara
Mar 19, 1999·The Journal of Veterinary Medical Science·T TakeuchiM Uehara
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J P Kraehenbuhl, M R Neutra
Feb 24, 2001·Journal of Anatomy·H KitagawaM Uehara
Mar 26, 2003·The Journal of Veterinary Medical Science·Hiroshi KitagawaMasato Uehara
Citations
Aug 8, 2014·Biotechnology Advances·Bibi F ChoonaraViness Pillay
Dec 3, 2005·BMC Cell Biology·Dorina RusuGuy Dandrifosse
Mar 11, 2010·Veterinary Research Communications·Feyzullah BeyazL Ergün
Jul 3, 2010·Cell and Tissue Research·Feyzullah BeyazLevent Ergün
Jul 29, 2005·Immunological Reviews·Julie MachAlexander Chervonsky
Dec 7, 2007·The Journal of Veterinary Medical Science·Sachiko OnishiHiroshi Kitagawa
Sep 27, 2005·Drug Discovery Today·David J BraydenAlan W Baird
Jan 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei XingChong-Su Cho