Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens

Cancer Chemotherapy and Pharmacology
Norman E SládekDavid T Kiang

Abstract

In preclinical models, established molecular determinants of cellular sensitivity to cyclophosphamide, long a mainstay of chemotherapeutic regimens used to treat breast cancers, include the aldehyde dehydrogenases that catalyze the detoxification of this agent, namely, ALDH1A1 and ALDH3A1. As judged by bulk quantification of relevant catalytic activities, as well as of relevant proteins (ELISAs), tissue levels of these enzymes vary widely in primary and metastatic breast malignancies. Thus, interindividual variation in the activity of either of these enzymes in breast cancers could contribute to the wide variation in clinical responses obtained when such regimens are used to treat these malignancies. Direct evidence for this notion was sought in the present investigation. Cellular levels of ALDH1A1 and ALDH3A1 in 171 repository human breast tumor (122 primary and 49 metastatic) samples were semiquantified using immunocytochemical staining. Clinical responses were retrieved from the archived medical records of each of 48 metastatic breast cancer sample donors, 26 of whom had been treated with a cyclophosphamide-based chemotherapeutic regimen subsequent to tumor sampling and 22 of whom had not. The premise that cellular levels of...Continue Reading

Citations

Jun 25, 2008·Stem Cells and Development·Julie DouvilleDanuta Balicki
Jun 7, 2011·Cancer Research·Malcolm H LawsonGillian Murphy
Feb 9, 2008·Pharmacology·Howard R Mellor, Richard Callaghan
Nov 10, 2010·Breast Cancer Research : BCR·Edgardo Rivera, Henry Gomez
Aug 24, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Satori A MarchittiVasilis Vasiliou
Nov 28, 2013·Virchows Archiv : an International Journal of Pathology·Julien CalderaroJessica Zucman-Rossi
Apr 26, 2014·British Journal of Cancer·J YanD Tang
Jun 8, 2011·Clinical & Experimental Metastasis·Christel van den HoogenGabri van der Pluijm
Nov 23, 2010·Expert Review of Vaccines·Patrycja J Lech, Stephen J Russell
Aug 8, 2012·The Journal of Cell Biology·Irène Baccelli, Andreas Trumpp
Jul 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna GiebułtowiczJacek Wierzchowski
Jan 6, 2006·Drug Metabolism Reviews·Jing ZhangYi-Zhun Zhu
Nov 22, 2007·Expert Opinion on Drug Metabolism & Toxicology·Michael Michael, Margaret M Doherty
Jul 10, 2008·Expert Opinion on Drug Metabolism & Toxicology·Satori A MarchittiVasilis Vasiliou
Oct 9, 2015·Clinical & Experimental Metastasis·Mauricio Rodriguez-Torres, Alison L Allan
Mar 3, 2009·Seminars in Radiation Oncology·Catherine Adell O'BrienJohn E Dick
Apr 30, 2014·Journal of Experimental & Clinical Cancer Research : CR·Evandro Luís NieroGláucia Maria Machado-Santelli
May 15, 2015·Pathology Oncology Research : POR·Pu-xiang ChenZhulin Yang
Oct 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying-Hui SongLi Li
Jul 28, 2016·Cancer Letters·Athanasia PavlopoulouAlexandros G Georgakilas
Sep 13, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jing ZhangShufeng Zhou
Dec 31, 2011·Free Radical Biology & Medicine·G MuzioR A Canuto
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Michael, M M Doherty
Dec 17, 2014·Journal of Lipid Research·Samuel L ArnoldNina Isoherranen
Nov 21, 2016·Carcinogenesis·Mohammad SultanPaola Marcato
Jan 1, 2011·Cancers·Ulrike OlszewskiGerhard Hamilton
Apr 26, 2017·World Journal of Clinical Oncology·Pierre V CandelariaRuben R Gonzalez-Perez

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