Cellular Li+ opens paracellular path in toad skin: amiloride blockable effect

The Journal of Membrane Biology
J AboulafiaF Lacaz-Vieira

Abstract

The presence of Li in the solution bathing the outer surface of toad skin under short-circuit condition promotes an unspecific permeability increase characterized by a delayed and progressive increase in the effluxes of 24Na, 42K and 14C sucrose. The effect of Li upon sucrose permeability might indicate an increased permeability of the paracellular pathway. The Li effect is mediated by an intracellular action since blockade of Li entrance into the cell compartment by amiloride prevents the increase in Na, K and sucrose permeability. A possible mechanism of this effect is discussed in terms of a disturbance in the cellular Ca++ balance leading to an increase in cytosolic Ca++ concentration which perturbs the organization of the cytoskeleton and the interplay between cytoskeleton and tight junctions.

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Citations

Jun 1, 1984·Pflügers Archiv : European journal of physiology·J Aboulafia, F Lacaz-Vieira
Feb 1, 1985·Pflügers Archiv : European journal of physiology·S M Sanioto, J Aboulafia
Jun 1, 1987·Pflügers Archiv : European journal of physiology·S M Sanioto, A Sesso
Jan 1, 1985·The Journal of Membrane Biology·J Aboulafia, F Lacaz-Vieira
Feb 1, 1995·In Vitro Cellular & Developmental Biology. Animal·K M Morshed, K E McMartin

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