Cellular life span and the Warburg effect

Experimental Cell Research
Hiroshi Kondoh

Abstract

Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo. Enhanced glycolysis is essential both in the step of immortalization and transformation, as it renders cells resistant to oxidative stress and adaptive to hypoxic condition, respectively. ES, immortalized primary, and cancerous cells display the common concerted metabolic shift, including enhanced glycolysis with reduced mitochondrial respiration by poorly characterized mechanism. Discovery of a novel regulatory mechanism for such a metabolic shift might be essential for the future development of cancer diagnosis and anti-cancer therapy.

References

May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·Q ChenB N Ames
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H ShimC V Dang
Jun 24, 1998·Genes & Development·J WangG J Hannon
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·L D Attardi, T Jacks
Mar 31, 1999·Trends in Biochemical Sciences·C V Dang, G L Semenza
Aug 17, 1999·Seminars in Cancer Biology·K L Braithwaite, P H Rabbitts
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 31, 2000·Cell·C J Sherr, R A DePinho
Nov 8, 2001·Current Opinion in Cell Biology·M Serrano, M A Blasco
Jun 29, 2002·Nature Biotechnology·Woodring E Wright, Jerry W Shay
Aug 22, 2002·The Journal of Biological Chemistry·Tali Shalom-Barak, Ulla G Knaus
Dec 12, 2002·The Journal of Biological Chemistry·Violeta SerraGabriele Saretzki
Dec 17, 2002·Molecular and Cellular Biology·Koji ItahanaGoberdhan P Dimri
Jun 3, 2004·Cancer Research·Rebecca L ElstromCraig B Thompson
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Mar 1, 2005·Biochimie·David Carling
Mar 23, 2005·Cancer Research·Jesús GilDavid Beach
Oct 4, 2005·Nature Biotechnology·Michael J EvansBenjamin F Cravatt
May 27, 2006·Science·Satoaki MatobaPaul M Hwang
Aug 19, 2006·Science·Julie M PinkstonCynthia Kenyon

❮ Previous
Next ❯

Citations

Apr 25, 2013·The International Journal of Biochemistry & Cell Biology·Qinsheng DaiQinglong Guo
May 28, 2014·BioMed Research International·Wanxing DuanQingyong Ma
Jun 1, 2014·Stem Cells and Development·Hiroyuki MoriyamaTakao Hayakawa
Jul 12, 2014·Human Reproduction Update·Sandro L PereiraJoão Ramalho-Santos
Jul 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Richard N Re, Julia L Cook
Apr 13, 2011·PloS One·Alberto MirandaAlfonso Gutierrez-Adan
Aug 25, 2011·The Journal of Biological Chemistry·Joanna Zawacka-PankauGalina Selivanova
Nov 11, 2011·International Journal of Molecular Sciences·Chaoyang XuRengui Fang
Sep 19, 2009·Cell Biology and Toxicology·Roland SchuchtTobias May
Mar 1, 2011·Progress in Retinal and Eye Research·Alan W StittReinhold J Medina
Dec 17, 2009·Mitochondrion·Gyorgy Baffy
Jan 20, 2010·Cancer Genetics and Cytogenetics·Ioannis P TrougakosEfstathios S Gonos
May 14, 2008·Experimental Cell Research·Fabrizio d'Adda di Fagagna
Dec 10, 2013·Journal of Pineal Research·Francisco E Martin-CanoPedro J Camello
Jan 23, 2014·Stem Cells·Masahiro AbeToshio Matsumoto
Jul 17, 2010·Yonsei Medical Journal·Hideshi IshiiMasaki Mori
May 9, 2014·Experimental Biology and Medicine·Shao-Chieh LinShaw-Jenq Tsai
Sep 7, 2016·Biochemical and Biophysical Research Communications·Xiang-Zhen KongXiao-Jian Zhang
Dec 18, 2014·Brazilian Dental Journal·Clarissa Favero DemedaLeão Pereira Pinto
Nov 11, 2017·Journal of Huntington's Disease·Janet M Dubinsky
Apr 30, 2019·Critical Reviews in Biotechnology·Matías Gutiérrez-GonzálezClaudia Altamirano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Trends in Biochemical Sciences
C V Dang, Gregg L Semenza
Molecular Cancer
Matilde E LleonartHiroshi Kondoh
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Feng YaoHeng Zhao
© 2022 Meta ULC. All rights reserved