Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Sandy LiuJinru Shia

Abstract

Blockade of the interaction between PD-1 and its ligands PD-L1 has shown clinical efficacy across several tumor types, especially in mismatch-repair-deficient colorectal carcinoma. The aim of this study was to examine the pattern and cellular localization of PD-L1 expression in the different molecular subtypes of mismatch-repair-deficient colorectal cancers vs. their mismatch-repair-proficient counterparts. PD-L1/SATB2 double-antibody-immunohistochemistry was utilized to distinguish tumor cell from immune cell staining. We observed in our series of 129 colorectal adenocarcinomas that PD-L1 expression occurred primarily in tumor-associated-immune cells and most prominently at the tumor-stroma-interface of the invasive front. The level of invasive front immune cell staining was significantly higher in mismatch-repair-deficient tumors compared to mismatch-repair-proficient tumors (p < 0.001), but no difference was observed among the different subtypes of mismatch-repair-deficient tumors: Lynch syndrome-associated vs. MLH1-methylated vs. unexplained. While selected mismatch-repair-proficient tumors exhibited unusually high tumor-infiltrating-lymphocytes and had high level immune cell PD-L1 expression, a positive correlation between...Continue Reading

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Citations

Feb 10, 2019·Journal of Personalized Medicine·Stergios BoussiosNicholas Pavlidis
Jul 17, 2020·Frontiers in Molecular Biosciences·Nives Pećina-ŠlausAnja Bukovac
Apr 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lisa A FriedmanAnne M Mills
Feb 14, 2021·NPJ Precision Oncology·Christopher S HongE Zeynep Erson-Omay
Mar 31, 2021·Neurosurgery Clinics of North America·Nalin LeelatianRanjit S Bindra
Apr 23, 2021·Cancer Immunology, Immunotherapy : CII·William RodinMarianne Quiding Järbrink

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Methods Mentioned

BETA
PCR
surgical resection

Software Mentioned

JMP®
LOWESS
Promega Analysis System

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