PMID: 6979553Jun 1, 1982Paper

Cellular localization of rheumatoid factor idiotypes

The Journal of Clinical Investigation
V R BonaguraB Pernis

Abstract

the stimulation of lymphocytes from rheumatoid arthritis patients with pokeweed mitogen produces a large number of plasma cells that express the dominant cross-reactive idiotype previously found on monoclonal IgM anti-gamma-globulins from patients with mixed cryoglobulinemia. Similar experiments with the cells of normal individuals show a much lower percentage of these cells with a lower intensity of staining with the fluorescent reagents utilized. Efforts to demonstrate rheumatoid factor in the same cells by fluorescent staining with aggregated gammaglobulin were entirely unsuccessful. This also proved to be the case for pokeweed mitogen-stimulated cells from the mixed cryoglobulinemic patients with large amounts of rheumatoid factor in the serum, despite high percentages of cells expressing the cross-reactive idiotype and also the individual idiotype. On the other hand, native plasma cells from synovial tissue of rheumatoid arthritis patients showed some cells with both the cross-reactive idiotype and aggregate staining. The exact reason for the failure to demonstrate rheumatoid factor by aggregate staining in pokeweed mitogen-stimulated cultures remains to be determined despite considerable effort to resolve the problem. The...Continue Reading

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Citations

Oct 1, 1993·Arthritis and Rheumatism·G AbelV Agnello
Jan 1, 1984·Rheumatology International·B PernisH G Kunkel
Sep 1, 1986·Journal of Clinical Immunology·J L Pasquali, D Storck
Jan 1, 1988·Springer Seminars in Immunopathology·V Agnello
Jan 1, 1983·Springer Seminars in Immunopathology·I M RoittP M Lydyard
Jan 1, 1988·Springer Seminars in Immunopathology·C G Winearls, J G Sissons
Sep 1, 1983·The Journal of Experimental Medicine·A N TheofilopoulosF J Dixon
Oct 1, 1991·Scandinavian Journal of Immunology·N T IlowiteV R Bonagura
Aug 1, 1995·Scandinavian Journal of Immunology·V Agnello
Aug 1, 1985·The Journal of Clinical Investigation·R HalpernB Diamond
Jan 1, 1989·International Reviews of Immunology·V R BonaguraJ F Wedgwood
May 1, 1992·Clinical Immunology and Immunopathology·R Suenaga, N I Abdou
Jan 1, 1983·Annals of the New York Academy of Sciences·H G KunkelB Pernis
Feb 1, 1996·Rheumatic Diseases Clinics of North America·V Agnello, P L Romain
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·R A MageedR Jefferis
Jun 1, 1983·Immunology Today·A CookeI M Roitt
Feb 1, 1986·Scandinavian Journal of Immunology·D N PosnettH G Kunkel

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