PMID: 2444983Nov 1, 1987Paper

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

Proceedings of the National Academy of Sciences of the United States of America
F ThiebautM C Willingham

Abstract

Monoclonal antibody MRK16 was used to determine the location of P-glycoprotein, the product of the multidrug-resistance gene (MDR1), in normal human tissues. The protein was found to be concentrated in a small number of specific sites. Most tissues examined revealed very little P-glycoprotein. However, certain cell types in liver, pancreas, kidney, colon, and jejunum showed specific localization of P-glycoprotein. In liver, P-glycoprotein was found exclusively on the biliary canalicular front of hepatocytes and on the apical surface of epithelial cells in small biliary ductules. In pancreas, P-glycoprotein was found on the apical surface of the epithelial cells of small ductules but not larger pancreatic ducts. In kidney, P-glycoprotein was found concentrated on the apical surface of epithelial cells of the proximal tubules. Colon and jejunum both showed high levels of P-glycoprotein on the apical surfaces of superficial columnar epithelial cells. Adrenal gland showed high levels of P-glycoprotein diffusely distributed on the surface of cells in both the cortex and medulla. These results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into t...Continue Reading

References

Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H Hamada, T Tsuruo
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A T FojoI Pastan
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I B RoninsonI Pastan
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K UedaI Pastan
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D J FitzGeraldI Pastan
May 28, 1987·The New England Journal of Medicine·I Pastan, M Gottesman

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Citations

Aug 1, 1996·Cancer·J D Ahlgren
Aug 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G H MickischM M Gottesman
Jan 30, 2007·Inflammatory Bowel Diseases·S ArdizzoneG Bianchi Porro
Dec 11, 2008·Inflammatory Bowel Diseases·Elizabeth M StaleyRobin G Lorenz
Feb 1, 1997·Journal of Clinical Pharmacology·R M LushW D Figg
Jul 12, 2002·Journal of Biochemical and Molecular Toxicology·David S Miller
Dec 1, 1990·Journal of Cellular Physiology·G BradleyV Ling
Jul 12, 2002·Microscopy Research and Technique·Reina BendayanMoise Bendayan
May 1, 1995·Molecular Carcinogenesis·J A Silverman, B A Hill
Apr 25, 2000·Biochemical and Biophysical Research Communications·E RocchiE Schneider
May 1, 1994·The Histochemical Journal·A MacFarlandC K Pearson
Jan 1, 1996·Investigational New Drugs·J F Kuttesch
Jan 1, 1991·Acta Neuropathologica·I BeckerV Höllt
Jun 1, 1993·Pflügers Archiv : European journal of physiology·C D BrownN L Simmons
Apr 1, 1994·Pflügers Archiv : European journal of physiology·M Diener, E Scharrer
Jan 1, 1994·Breast Cancer Research and Treatment·R I Glazer, C Rohlff
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·K V Speeg, A L Maldonado
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·K E WoodsD A Gewirtz
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·S E BatesL J Elwood
Jun 1, 1994·Cancer Metastasis Reviews·G Bradley, V Ling
Jan 1, 1993·Cytotechnology·J M Croop
Jan 1, 1993·Cytotechnology·U A Germann

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