Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity

Journal of Applied Toxicology : JAT
S Homma-TakedaYoshiya Shimada

Abstract

Renal toxicity is a hallmark of uranium exposure, with uranium accumulating specifically in the S3 segment of the proximal tubules causing tubular damage. As the distribution, concentration and dynamics of accumulated uranium at the cellular level is not well understood, here, we report on high-resolution quantitative in situ measurements by high-energy synchrotron radiation X-ray fluorescence analysis in renal sections from a rat model of uranium-induced acute renal toxicity. One day after subcutaneous administration of uranium acetate to male Wistar rats at a dose of 0.5 mg uranium kg(-1) body weight, uranium concentration in the S3 segment of the proximal tubules was 64.9 ± 18.2 µg g(-1) , sevenfold higher than the mean renal uranium concentration (9.7 ± 2.4 µg g(-1) ). Uranium distributed into the epithelium of the S3 segment of the proximal tubules and highly concentrated uranium (50-fold above mean renal concentration) in micro-regions was found near the nuclei. These uranium levels were maintained up to 8 days post-administration, despite more rapid reductions in mean renal concentration. Two weeks after uranium administration, damaged areas were filled with regenerating tubules and morphological signs of tissue recovery...Continue Reading

References

May 1, 1990·Health Physics·S Lu, F Y Zhao
Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·F N GhadiallyS Yang-Steppuhn
Jul 1, 1997·Reviews on Environmental Health·D M Taylor, S K Taylor
Oct 23, 2004·Nephron. Physiology·Jack G KleinmanJeremy Hughes
Aug 4, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yoshihide FujigakiAkira Hishida
Apr 17, 2007·Chemical Research in Toxicology·Wendy J HartsockDavid J Segal
Aug 10, 2007·Environmental Health Perspectives·H Sonali MagdoPhilip J Landrigan
Aug 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Odette PratEric Quéméneur
Sep 16, 2010·Protein Science : a Publication of the Protein Society·Olivier PibleEric Quéméneur
Nov 12, 2010·Chemical Research in Toxicology·Caroline RouasYann Gueguen
Apr 27, 2013·Journal of Applied Toxicology : JAT·Shino Homma-TakedaYoshiya Shimada
Jul 5, 2013·Chemistry : a European Journal·Samir SafiChristophe Den Auwer

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Citations

Oct 16, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Darcy K WeidemannJeffrey J Fadrowski
Apr 17, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katherine E ZychowskiMatthew J Campen
Mar 1, 2017·Journal of Synchrotron Radiation·Keisuke KitaharaShino Homma-Takeda
Nov 17, 2020·Biophysics and Physicobiology·Hitomi Sawai, Koichiro Ishimori

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