Cellular location and major terminal networks of the orexinergic system in the brains of five microchiropteran species

Journal of Chemical Neuroanatomy
Jean-Leigh KrugerPaul R Manger

Abstract

The present study describes the distribution of Orexin-A immunoreactive cell bodies and terminal networks in the brains of five microchiropteran species. Given the specialized flight and echolocation abilities of the microchiropterans it was of interest to examine if any specific differences in a generally phylogenetically homogenous neural system could be found. The orexinergic neurons have been found within the hypothalamus of all species studied, and were represented by a large cluster that spanned the anterior, dorsomedial, perifornical and lateral hypothalamic regions, with a smaller cluster extending into the region of the medial zona incerta. Evidence for orexinergic neurons in the ventrolateral hypothalamus adjacent to the optic tract was not observed in any microchiropteran species. The terminal networks of the orexinergic neurons conformed to that previously reported in a range of mammalian species, with dense terminal networks being found in the hypothalamus, cholinergic pedunculopontine and laterodorsal tegemental nuclei, the noradrenergic locus coeruleus complex, all serotonergic nuclei, the paraventricular nuclei of the epithalamus and adjacent to the habenular nuclei. Thus, apart from the lack of neurons in the v...Continue Reading

References

Aug 2, 2000·Trends in Endocrinology and Metabolism : TEM·W K Samson, Z T Resch
Nov 5, 2003·Frontiers in Neuroendocrinology·Alastair V Ferguson, Willis K Samson
Feb 24, 2004·Annual Review of Physiology·Fritz Geiser
Sep 20, 2005·Brain Research·Gilbert J KirouacSa Li
Jan 2, 2010·Journal of Chemical Neuroanatomy·Kaare S EttrupCarsten R Bjarkam

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Citations

Sep 18, 2013·Journal of Chemical Neuroanatomy·Leigh-Anne DellPaul R Manger
Nov 26, 2010·Journal of Chemical Neuroanatomy·Adhil BhagwandinPaul R Manger
Aug 2, 2015·Journal of Chemical Neuroanatomy·Leigh-Anne DellPaul R Manger
Nov 21, 2015·The Journal of Comparative Neurology·Leigh-Anne DellPaul R Manger
Nov 21, 2015·The Journal of Comparative Neurology·Leigh-Anne DellPaul R Manger
Sep 5, 2014·PloS One·Kyle E GoddenMaria Pompeiano
Oct 27, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Richard ChawanaPaul R Manger
Jul 6, 2021·Metabolic Brain Disease·Idris A AzeezJames O Olopade
Sep 18, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Victoria M WilliamsPaul R Manger

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