Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport

Annual Review of Cell and Developmental Biology
Mithila Burute, Lukas C Kapitein

Abstract

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein-based intracellular transport. Microtubule networks are highly diverse across different cell types and are believed to adapt to cell type-specific transport demands. Here we review how the spatial organization of different subsets of microtubules into higher-order networks determines the traffic rules for motor-based transport in different animal cell types. We describe the interplay between microtubule network organization and motor-based transport within epithelial cells, oocytes, neurons, cilia, and the spindle apparatus.

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Citations

Mar 21, 2020·Journal of Neurochemistry·Aleksandra TempesJacek Jaworski
Jun 7, 2020·Cells·Robert BeckerFelix B Engel
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shiwen LiuC Yan Cheng
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Apr 21, 2021·Neuroscience Letters·Graziella CappellettiChiara Rolando
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Sadhana Panzade, Maja Matis
Jul 28, 2021·ELife·Eugene A KatrukhaLukas C Kapitein
Oct 29, 2021·Development·Azelle HawdonJennifer Zenker
Oct 24, 2021·Biophysical Journal·Saurabh S MogreElena F Koslover

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Methods Mentioned

BETA
dissection
acetylation
electron microscopy
electron micrography
super-resolution microscopy

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