PMID: 15394073Dec 1, 1949Paper

Cellular mechanisms of antibacterial defense in lymph nodes; pathogenesis of acute bacterial lymphadenitis

The Journal of Experimental Medicine
R O SMITH, W B WOOD

Abstract

Acute pneumococcic lymphadenitis produced in rats by intradermal inoculation of the foot-pad is characterized by rapid infiltration of polymorphonuclear leucocytes into the intermediary sinuses of the node, and prompt phagocytosis of pneumococci by both the macrophages of the sinuses and the recently arrived leucocytes. After 5 to 7 hours the polymorphonuclear leucocytes are found densely congregated about the hilar region, and 9 hours after inoculation most of the phagocyted organisms have been digested. At the end of the 24 hour period the popliteal node presents the picture of a subsiding inflammation with a marked macrophage reaction and regenerating lymph follicles. Phagocytosis of encapsulated pneumococci in the foot-pad and popliteal node occurs in less than 30 minutes after inoculation. It is assumed that this prompt phagocytosis is effected by the non-antibody mechanism of "surface phagocytosis." The majority of polymorphonuclear leucocytes that enter the sinuses of the inflamed node appear to come from capillaries within the node itself rather than from the primary site of inflammation in the foot-pad. The prompt inflammatory response of the nodal tissues serves as an active defense against lymph-borne infection. Macr...Continue Reading

Citations

Oct 1, 1959·The Journal of Experimental Medicine·M J FOLEYW B WOOD
Jan 1, 1963·American Journal of Surgery·N FLEISIG, M A HAYES
Jul 21, 2017·The Bulletin of Tokyo Dental College·Masashi MigitaTakahiko Shibahara
Jun 3, 2021·International Journal of Molecular Sciences·Kazuki Nagata, Chiharu Nishiyama

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