Cellular mechanisms of the epilepsies: In vitro studies on human tissue

Neuro-Chirurgie
J LaschetRené Pumain

Abstract

Animal models have provided very valuable data to specify the physiopathological mechanisms of the various forms of epilepsy. However, the question arises of knowing which of these experimental results are relevant to the human epileptic brain. The development of epileptic surgery makes it possible to directly study the functional properties of human brain tissue in vitro and to analyze the mechanisms underlying seizures and epileptogenesis. We review some of the results obtained over the last few years in our laboratory based on electrophysiological, immunocytochemical and molecular experiments conducted on human brain tissue. This review covers a number of the mechanisms of neuronal synchronizations generating epileptiform discharges, including the role of electrical synapses connecting the inhibitory interneurons, particularly in Taylor-type focal cortical dysplasia and the functional lability of GABAergic inhibition in epileptogenic human cortical tissue, which may sustain triggering and propagation of seizures. Some of these mechanisms have not been described in animal models. Studies on human tissue, when carefully designed, are necessary to validate the data collected on animal models and will continue to provide us with...Continue Reading

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Aug 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott J CruikshankMiduturu Srinivas
Sep 3, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacques J LaschetRené Pumain
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Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jacques J LaschetRené Pumain
Aug 30, 2007·Critical Reviews in Neurobiology·René Pumain, Jacques Laschet

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