Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis

American Journal of Physiology. Cell Physiology
David Lu, P A Insel

Abstract

Tissue fibrosis occurs as a result of the dysregulation of extracellular matrix (ECM) synthesis. Tissue fibroblasts, resident cells responsible for the synthesis and turnover of ECM, are regulated via numerous hormonal and mechanical signals. The release of intracellular nucleotides and their resultant autocrine/paracrine signaling have been shown to play key roles in the homeostatic maintenance of tissue remodeling and in fibrotic response post-injury. Extracellular nucleotides signal through P2 nucleotide and P1 adenosine receptors to activate signaling networks that regulate the proliferation and activity of fibroblasts, which, in turn, influence tissue structure and pathologic remodeling. An important component in the signaling and functional responses of fibroblasts to extracellular ATP and adenosine is the expression and activity of ectonucleotideases that attenuate nucleotide-mediated signaling, and thereby integrate P2 receptor- and subsequent adenosine receptor-initiated responses. Results of studies of the mechanisms of cellular nucleotide release and the effects of this autocrine/paracrine signaling axis on fibroblast-to-myofibroblast conversion and the fibrotic phenotype have advanced understanding of tissue remodel...Continue Reading

References

Jan 1, 1996·Annual Review of Biochemistry·D A GoodenoughD L Paul
Dec 8, 1998·The Biochemical Journal·S P Kunapuli, J L Daniel
Mar 23, 2000·Journal of Hepatology·D A BrennerR A Rippe
Jun 27, 2000·The Journal of Biological Chemistry·F M GribbleF M Ashcroft
Aug 22, 2000·Journal of Hepatology·A P FeranchakR M Roman
Oct 24, 2000·Kidney International·J P RerolleE P Rondeau
Apr 23, 2002·Kidney International·Oliver VonendLars Christian Rump
Aug 24, 2002·Circulation Research·Robert A KaiserIain L O Buxton
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jonathan A DranoffJean Sévigny
Jan 30, 2003·Journal of Cardiac Failure·Jack P M Cleutjens, Esther E J M Creemers
Sep 25, 2003·Physiological Reviews·Juan C SaezEric C Beyer
Nov 8, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·David GatofJ Gregory Fitz
Dec 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Juan M Gómez-HernándezLuis C Barrio
Jan 31, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michael Zeisberg, Raghu Kalluri
Feb 7, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jonathan A DranoffRebecca G Wells
Mar 11, 2004·Journal of Molecular and Cellular Cardiology·Mohammed Shakil AhmedHåvard Attramadal
Jul 28, 2004·Cardiovascular Research·Stephan Rosenkranz
Dec 24, 2004·The Journal of Biological Chemistry·Julian ThimmRatnesh Lal
Dec 29, 2004·Cardiovascular Research·Patrizia CamellitiPeter Kohl
Apr 1, 2005·The Journal of Biological Chemistry·M Nauman JhandierJonathan A Dranoff
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janci L ChunnMichael R Blackburn
Nov 1, 2005·Pharmacology & Therapeutics·Ivar von Kügelgen
Nov 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marta Ruiz-OrtegaJesús Egido
Feb 24, 2006·Trends in Cell Biology·Michael Koval
Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Troy A BaudinoThomas K Borg
Jun 7, 2006·The Journal of Biological Chemistry·Seiko F OkadaRichard C Boucher
Jun 20, 2006·British Journal of Pharmacology·Edwin S L ChanBruce N Cronstein
Aug 22, 2006·Cardiovascular Research·Andrew Leask
Nov 18, 2006·Cardiovascular Research·Marcin Bujak, Nikolaos G Frangogiannis
Dec 16, 2006·Science·Yu ChenWolfgang G Junger

❮ Previous
Next ❯

Citations

Dec 17, 2015·Annual Review of Physiology·János Peti-PeterdiJennifer L Pluznick
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Ana RamírezJavier Camacho
Sep 24, 2015·Purinergic Signalling·Safoura MazroueiMaria Wartenberg
Aug 16, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zoubir DjeradaHervé Millart
Oct 27, 2016·Kidney International·Robert I MenziesMatthew A Bailey
May 4, 2017·Journal of Cellular Biochemistry·A S Martínez-RamírezF G Vázquez-Cuevas
Nov 26, 2016·Fundamental & Clinical Pharmacology·Thomas GicquelVincent Lagente
Jan 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaofei CongXiaoli Zhao
Nov 2, 2014·The Journal of Pharmacology and Experimental Therapeutics·Hong-Wei Yao, Jun Li
Feb 23, 2018·Science Translational Medicine·Naoki TakemuraSatoshi Uematsu
Feb 11, 2020·British Journal of Pharmacology·Kenneth A JacobsonChrista E Müller
Dec 14, 2017·Purinergic Signalling·Charlotte RoyGilles Kauffenstein
Sep 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Davide FerrariBruce Cronstein
May 27, 2020·Médecine sciences : M/S·Amelle ChouiterOlivier Dellis
Sep 25, 2019·Journal of Cardiovascular Development and Disease·Jianlin FengLixia Yue
Dec 3, 2016·Purinergic Signalling·A S Martínez-RamírezF G Vázquez-Cuevas
May 23, 2017·Frontiers in Pharmacology·Elizabeth A VecchioLauren T May
Nov 26, 2020·International Journal of Molecular Sciences·Ivana NovakGanga Deshar
Nov 18, 2020·International Journal of Molecular Sciences·Carla Trapero, Mireia Martín-Satué
Apr 1, 2021·Regenerative Medicine·Fan YangYong Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.