Cellular mechanisms responsible for cell-to-cell spreading of prions

Cellular and Molecular Life Sciences : CMLS
Didier VilettePascal Leblanc

Abstract

Prions are infectious agents that cause fatal neurodegenerative diseases. Current evidence indicates that they are essentially composed of an abnormally folded protein (PrPSc). These abnormal aggregated PrPSc species multiply in infected cells by recruiting and converting the host PrPC protein into new PrPSc. How prions move from cell to cell and progressively spread across the infected tissue is of crucial importance and may provide experimental opportunity to delay the progression of the disease. In infected cells, different mechanisms have been identified, including release of infectious extracellular vesicles and intercellular transfer of PrPSc-containing organelles through tunneling nanotubes. These findings should allow manipulation of the intracellular trafficking events targeting PrPSc in these particular subcellular compartments to experimentally address the relative contribution of these mechanisms to in vivo prion pathogenesis. In addition, such information may prompt further experimental strategies to decipher the causal roles of protein misfolding and aggregation in other human neurodegenerative diseases.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S B PrusinerR E Race
Jun 1, 1976·The Journal of General Virology·M C Clarke, G C Millson
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F DiedrichA T Haase
Feb 15, 1990·The Biochemical Journal·R Gabizon, S B Prusiner
Jan 1, 1987·The Journal of General Virology·M E Bruce, A G Dickinson
Oct 31, 1987·The Veterinary Record·G A WellsR Bradley
Apr 1, 1982·Annals of Neurology·S B PrusinerH M Martinez
Dec 24, 1982·Science·D C BoltonS B Prusiner
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·C A GutekunstS M Hersch
Jul 2, 1993·Cell·H BüelerC Weissmann
Oct 1, 1993·British Medical Bulletin·M E Bruce
Apr 6, 1996·Lancet·R G WillP G Smith
Jan 24, 1998·Science·B Chesebro
Oct 15, 1998·Nature Medicine·J SafarS B Prusiner
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K DenzerH J Geuze
Oct 20, 2000·The Journal of General Virology·M Glatzel, A Aguzzi
Apr 3, 2001·Annual Review of Neuroscience·J Collinge
Sep 5, 2001·Nature Medicine·F L HeppnerA Aguzzi
Dec 26, 2001·The Journal of General Virology·Fang-Ping HuangG Gordon MacPherson
Apr 9, 2002·Current Biology : CB·Nnennaya KanuJeremy P Brockes
Aug 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·C WeissmannE Flechsig
Mar 18, 2003·The Journal of Biological Chemistry·Ariel SavinaMaria I Colombo
Aug 20, 2003·The Journal of Cell Biology·Peter J PetersStanley B Prusiner
Aug 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GouldJames E K Hildreth
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·P-C KlöhnC Weissmann
Dec 17, 2003·Journal of Neurochemistry·Kenneth L MoyaLuigi Di Giamberardino
Dec 31, 2003·Developmental Biology·Enrique Salas-Vidal, Hilda Lomelí
Feb 14, 2004·Science·Amin RustomHans-Hermann Gerdes
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Benoit FevrierGraça Raposo
Aug 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sabrina CronierJean-Michel Peyrin
Oct 21, 2004·Nature Reviews. Microbiology·Charles Weissmann
Feb 1, 2005·Annals of the New York Academy of Sciences·Robin G Lorenz, Rodney D Newberry

❮ Previous
Next ❯

Citations

Oct 16, 2018·Frontiers in Cellular Neuroscience·Zsuzsanna SzepesiTomas Deierborg
Sep 3, 2020·International Journal of Molecular Sciences·Hideyuki Hara, Suehiro Sakaguchi
Oct 6, 2020·Frontiers in Bioengineering and Biotechnology·Jose A Del Rio, Isidre Ferrer
Jan 9, 2020·Frontiers in Neuroscience·Paul M Mathews, Efrat Levy
Feb 2, 2020·The Journal of Biological Chemistry·Mikahl Banwarth-Kuhn, Suzanne Sindi
Oct 24, 2020·International Journal of Molecular Sciences·Rodrigo Nunes AlvesMarilene Hohmuth Lopes
May 17, 2019·Current Opinion in Pharmacology·Dalia H AbdelazizHermann M Schatzl
Nov 27, 2021·Journal of Molecular Neuroscience : MN·Haoyang HuangSarita Lagalwar
Nov 1, 2021·Journal of Theoretical Biology·Fernando Alcalde CuestaÁlvaro Lozano Rojo

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.