Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling

Seminars in Cell & Developmental Biology
Karen L Neitzel, John R Hepler

Abstract

Regulators of G protein signaling (RGS proteins) bind directly to activated Galpha subunits to inhibit their signaling. However, recent findings show that RGS proteins selectively regulate signaling by certain G protein-coupled receptors (GPCRs) in cells, irrespective of the coupled G protein. New studies support an emerging model that suggests RGS proteins utilize both direct and indirect mechanisms to form stable functional pairs with preferred GPCRs to selectively modulate the signaling functions of those receptors and linked G proteins. Here, we discuss these findings and their implications for established models of GPCR signaling.

References

Jul 1, 1992·Scientific American·M E Linder, A G Gilman
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S P SrinivasaM E Linder
Jun 26, 1998·Science·T KozasaP C Sternweis
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·L De VriesM G Farquhar
Dec 18, 1998·The Journal of Biological Chemistry·W ZengT M Wilkie
Jan 28, 1999·The Journal of Biological Chemistry·X XuT M Wilkie
Nov 24, 1999·The Journal of Biological Chemistry·S P HeximerK J Blumer
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·L De VriesM G Farquhar
Apr 3, 2001·Trends in Cardiovascular Medicine·D A SierraT M Wilkie
Jul 18, 2002·Nature Reviews. Drug Discovery·Richard R Neubig, David P Siderovski
Sep 12, 2002·Pharmacological Reviews·Susanne Hollinger, John R Hepler
Oct 19, 2002·Circulation Research·Randy A Hall, Robert J Lefkowitz
Dec 5, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·R R Neubig
Aug 16, 2003·Molecular Pharmacology·John R Hepler
Apr 23, 2004·Trends in Pharmacological Sciences·Vsevolod V Gurevich, Eugenia V Gurevich
May 15, 2004·The Journal of Biological Chemistry·Qin WangRichard R Neubig
Jun 8, 2004·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·H ChoJ H Kehrl
Sep 10, 2004·Molecular Biology of the Cell·Freddy JeanneteauPierre Sokoloff
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott J BornheimerShankar Subramaniam
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Theresa M Cabrera-VeraHeidi E Hamm
Mar 23, 2005·Anesthesia and Analgesia·Guo-Xi Xie, Pamela Pierce Palmer
Aug 13, 2005·Cellular Signalling·Anju Anne RoyPeter Chidiac
Jan 26, 2006·Biochemical and Biophysical Research Communications·Irina G TikhonovaDaniel Fourmy

❮ Previous
Next ❯

Citations

Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Inigo Ruiz de AzuaJürgen Wess
Jan 22, 2009·IET Systems Biology·M R MauryaS Subramaniam
Nov 26, 2009·Nature Reviews. Molecular Cell Biology·Stefanie L Ritter, Randy A Hall
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nevin A LambertDavid P Siderovski
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunjia ChenQin Wang
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Yi-Chuan ChengChia-Jung Shen
Dec 15, 2015·Molecular Pharmacology·Kyle J GerberJohn R Hepler
Sep 13, 2011·Trends in Pharmacological Sciences·Christopher P VellanoJohn R Hepler
Nov 26, 2010·Trends in Endocrinology and Metabolism : TEM·Inigo Ruiz de AzuaJürgen Wess
Mar 26, 2009·European Journal of Pharmacology·Graham LaddsJohn Davey
Aug 19, 2008·Journal of Theoretical Biology·Dávid CsercsikGyörgy M Nagy
Nov 17, 2007·Pharmacology & Therapeutics·Geetanjali BansalZhihui Xie
Mar 14, 2007·Trends in Pharmacological Sciences·Stephen S G Ferguson
Apr 17, 2007·European Journal of Pharmacology·Zhihua XieLee-Yuan Liu-Chen
Jul 17, 2010·Annals of the New York Academy of Sciences·Mayumi Miyamoto-MatsubaraYumiko Saito
Mar 8, 2013·Journal of Receptor and Signal Transduction Research·Nan Sethakorn, Nickolai O Dulin
Sep 13, 2008·Current Biology : CB·Elliott M Ross
Oct 29, 2017·Journal of Neuroinflammation·Pierre J DoyenEmmanuel Hermans
Jul 23, 2011·Circulation Research·Peng Zhang, Ulrike Mende
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zhao YangMichael T Greenwood
Mar 1, 2012·Pflügers Archiv : European journal of physiology·Jie WuMinoru Horie
May 1, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Jacob KachNickolai O Dulin
Dec 31, 2016·Molecular Systems Biology·Alan BushAlejandro Colman-Lerner
Apr 28, 2018·Physiological Genomics·Katherine J PerschbacherJustin L Grobe
Oct 18, 2019·PLoS Biology·Nicholas T HendersonDaniel J Lew
Aug 7, 2019·The FEBS Journal·Christos KaroussiotisZafiroula Georgoussi
Jun 21, 2011·Nature Structural & Molecular Biology·Mickey KosloffVadim Y Arshavsky
Jun 28, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·David García-BernalJoaquin Teixidó
Jul 23, 2021·Cellular and Molecular Life Sciences : CMLS·Ali AsliMickey Kosloff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.