Cellular mechanisms underlying differential rejection of sequential heart and lung allografts in rats

Transplantation
F MollerC Clayberger

Abstract

As the simultaneous transplantation of two or more organs into a single recipient has become increasingly common, asynchronous allograft rejection has become an important clinical problem. To investigate the cellular and molecular mechanisms underlying differential organ rejection, we developed a rat model in which heart and lung allografts were transplanted sequentially. Heterotopic heart allografts transplanted into DA recipients from PVG donors survived indefinitely if the recipients were given a short course of rabbit antirat thymocyte globulin or cyclosporine at the time of transplantation. In contrast, orthotopic left lungs transplanted under the same conditions were rejected in ATG-treated recipients and accepted in most CsA-treated recipients. These animals were then given a second organ allograft from the same strain or a third party to assess whether they exhibited donor specific tolerance and whether the acceptance or rejection of the first allograft would influence the survival of the second transplant. Animals tolerized to a heart allograft with ATG rejected an orthotopic lung transplant from the same strain as the original allograft, whereas recipients treated with CsA at the time of their heart transplant accepte...Continue Reading

Citations

Apr 17, 2007·Langenbeck's Archives of Surgery·Veronika GrauWinfried Padberg
Jul 6, 2000·Peptides·S Persson-SjögrenI B Täljedal
Oct 24, 1998·Peptides·S Persson-SjögrenI B Täljedal
Sep 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lori J West, Kesheng Tao
Feb 8, 2006·Biological & Pharmaceutical Bulletin·Yong MaAkimasa Nakao
Oct 6, 1998·Cellular Immunology·E PeterssonH Ekberg

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