Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells

Cells
Ye ChenSong Guo Zheng

Abstract

Regulatory T cells (Tregs) are essential for maintaining immune tolerance and preventing autoimmune and inflammatory diseases. The activity and function of Tregs are in large part determined by various intracellular metabolic processes. Recent findings have focused on how intracellular metabolism can shape the development, trafficking, and function of Tregs. In this review, we summarize and discuss current research that reveals how distinct metabolic pathways modulate Tregs differentiation, phenotype stabilization, and function. These advances highlight numerous opportunities to alter Tregs frequency and function in physiopathologic conditions via metabolic manipulation and have important translational implications.

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Citations

Sep 5, 2019·Frontiers in Immunology·Sylvain De GuiseRandall S Wells
Jun 2, 2020·Frontiers in Immunology·Zhenkun WangSong Guo Zheng
Jun 24, 2020·Frontiers in Pharmacology·Giuseppe TerrazzanoGiuseppina Ruggiero
Oct 18, 2020·Cells·Shile Huang
Jun 1, 2021·Frontiers in Microbiology·Subhajit Maity, Abhik Saha
Aug 2, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ye ChenSong Guo Zheng

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Methods Mentioned

BETA
ubiquitination

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